Comparison of the cervical pathologic results in Low-Grade Squamous Intraepithelial Lesion (LSIL) cervical smear between HIV positive and HIV negative women
Keywords:
HIV positive, Pap smear, Prevalence, Cervical cancer, colposcopyAbstract
Objective: To determine the prevalence of abnormal cervical pathologic results from cervical tissue biopsy in women who had abnormal Pap smear LSIL, compared between HIV positive and HIV negative women.
Design: Retrospective Cross-sectional study
Background: Abnormal cervical lesion Low-Grade Squamous Intraepithelial Lesion (LSIL) may progress to High-Grade Intraepithelial Lesion which is a precursor of invasive cervical cancer. According to previous data, the prevalence of Abnormal cervical lesion in HIV positive women was estimated high and may progress to invasive cervical cancer more rapidly. Therefore, early detection of the abnormal cervical lesion could be useful for early treatment and reduce the incidence of invasive cervical cancer. This study aims to determine the prevalence of abnormal cervical pathology in LSIL cervical smear between HIV positive and HIV negative women.
Subjects: The 265 women with LSIL from Pap smear results who underwent colposcopic work up at Nakornping Hospital from October 2015 to September 2018. The study group was 60 HIV positive women and the comparative group was 205 HIV negative women.
Methods: The data were collected from medical records of colposcopic clinic Nakornping Hospital. The women who had LSIL from Pap smear and underwent cervical tissue biopsy due to abnormal colposcopic finding were included in this study. Pathologic results were explored to determine the prevalence and severity of the cervical abnormality. All associated data were compared between HIV positive and seronegative women
Results: HIV positive women with LSIL from Pap smear had a prevalence of abnormal cervical cell more than the prevalence of cervicitis or normal tissue. HIV infected women had LSIL from cervical tissue biopsy more than the HIV negative group significantly (Relative risk ratio 2.49, 95% Confident interval 1.29-4.78, p = 0.006). The prevalence of non-malignant pathologic results (Normal, Cervicitis) and high-grade lesion (HSIL, Carcinoma) was not different between the two groups.
Conclusions: Women with LSIL from Cervical smear should undergo colposcopic work up to identify actual abnormal cervical lesion especially HIV positive women who frequently had abnormal cervical tissue.
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