C24. Effect of Thai herbal recipes on the immune system in streptozotocin-induced diabetic retired breeder mice

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Supaporn Intatham
Parirat Khonsung
Phraepakaporn Kunnaja
Natthakarn Chiranthanut
Mingkwan Na Takuathung
Sunee Chansakaow
Seewaboon Sireeratawong Sireeratawong

Abstract

Introduction: The deterioration of the immune system occurs with increasing age. Additionally, impaired insulin secretion and decreased insulin sensitivity are associated with aging. Type 2 diabetes mellitus is related to immune dysfunction that causes the elderly with diabetes to have a higher risk of infection. Herbal-based treatments are one of the therapeutic strategies for reducing blood glucose and also rejuvenating the immune system to improve the quality of life of the elderly.


Objective: To investigate the immunomodulatory effect of two Thai herbal recipes in streptozotocin (STZ)-induced diabetic aging mouse model. Recipe 1 consisted of M. cochinchinensis, C. ternatea, and G. inodorum (1:1:1). Recipe 2 substituted C. zeylanicum for G. inodorum.


Methods: Thirty-week-old male mice with diabetes induced by STZ were orally administered with Thai herbal recipes at the doses of 250, 500, and 1,000 mg/kg for 28 days. Blood glucose monitoring was performed on days 7, 14, 21, and 28. After 28 days, mice were sacrificed, spleen and thymus were weighed. The peripheral white blood cell count and differential were measured.


Results: Treatment with both herbal recipes lowered blood sugar levels, however, the body weight loss could not improve in diabetic aging mice. Relative thymus weight seemed to increase in diabetic aging mice treated with a low dose of herbal recipe 1 and a high dose of herbal recipe 2. Additionally, diabetic aging mice treated with a low dose of herbal recipe 1 significantly increased relative spleen weight, whereas treatment with herbal recipe 2 at low and middle doses tended to decrease relative spleen weight. Treatment with both herbal recipes caused the diabetic aging mice to have a lower peripheral monocyte count. Nonetheless, treatment with a high dose of herbal recipe 1 significantly increased peripheral white blood cell (WBC), lymphocyte, and basophil counts.


Conclusion: This study demonstrated the immunomodulatory and hypoglycemic effects of two Thai herbal recipes in diabetic aging mice. Interestingly, Thai herbal recipe 1 tended to be able to boost the immune system.

Article Details

How to Cite
Intatham, S. ., Khonsung, P. ., Kunnaja, P. ., Chiranthanut, N. ., Na Takuathung, M. ., Chansakaow, S., & Sireeratawong, S. S. (2022). C24. Effect of Thai herbal recipes on the immune system in streptozotocin-induced diabetic retired breeder mice. Journal of Health Science and Alternative Medicine, 197–205. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthscialternmed/article/view/257796
Section
Original Article

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