C13. Effects of circRNA in Notch Pathway on Differentiation and Maturation of Oligodendrocyte Progenitor Cells in Cerebral Palsy
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Abstract
CircRNAs are ubiquitous non-coding RNAs, which are richly expressed in brain tissues and participate in the development and signaling of the nervous system and regulate complex functions and various neural activities of the brain. The Notch pathways can regulate multiple processes of cell morphology by regulating cell damage and apoptosis, inflammation, nerve repair and angiogenesis, and other processes involved in the occurrence and development of diseases. The Notch pathway critically regulates the differentiation and maturation of oligodendrocyte progenitor cells (OPCs), and the abnormal expression of circRNA can regulate the differentiation and maturation of OPCs through many pathways, including the Notch pathway, thus participating in the occurrence and development of cerebral palsy. This paper systematically reviewed the effects of circRNA on the differentiation and maturation of OPCs in cerebral palsy by regulating the Notch pathway to provide new ideas for the diagnosis, treatment, and research of cerebral palsy.
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