C10. A Systematic Review of Randomized Controlled Trial on Efficacy of Centella asiatica for Wound Healing
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Abstract
Introduction: The delay of wound healing leads to the risk of infection, chronic wound and other complications. Proper treatments for wound care will speed up the healing process and reduce scar formation. Centella asiatica is the famous medicinal plant among herbal skin care for healing both normal and chronic wounds with less adverse effects.
Objective: This systematic review was performed to evaluate the wound healing properties of C. asiatica in clinical trials.
Methods: A pre-registered systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search strategy and three electronic databases including PubMed, ScienceDirect and Google Scholar were used in this study. We had intended to perform a meta-analysis, but this was not possible due to variation in study design and reporting. The search strategy identified 1,410 articles through selected databases and 5 clinical trials met the inclusion criteria for quantitative synthesis. The quality assessment for risk of bias of the selected studies was evaluated by Cochrane risk of bias tool. The inclusion criteria were randomized controlled trials. We included participants with wounds regardless of age, gender, and ethnicity. The different types of wound are burn wound, diabetic foot ulcer, hypertrophic scar, split-thickness skin graft, and post laser resurfacing.
Results: The favorable effect of C. asiatica was observed with a quicker wound healing, possibly due to the synthesis of collagen type 1, 2, and 3, stimulation of fibronectin, and remodeling of the extracellular matrix. Furthermore, C. asiatica has a beneficial effect on anti-inflammation and increases tensile strength, accelerating the formation of epithelium and keratin.
Conclusion: C. asiatica may have beneficial effects on wound healing; however, more clinical trials are needed in order to perform a meta-analysis to ensure the wound healing effects of the plant in different parameters.
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