C10. A Systematic Review of Randomized Controlled Trial on Efficacy of Centella asiatica for Wound Healing

Main Article Content

Parichart Hongsing
Kiattiya Areesuk
Natcha Atsalikon
Rutchaneekorn Pitiwattanakulchai
Chin Jai Wei

Abstract

Introduction: The delay of wound healing leads to the risk of infection, chronic wound and other complications. Proper treatments for wound care will speed up the healing process and reduce scar formation. Centella asiatica is the famous medicinal plant among herbal skin care for healing both normal and chronic wounds with less adverse effects.


Objective: This systematic review was performed to evaluate the wound healing properties of C. asiatica in clinical trials.


Methods: A pre-registered systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search strategy and three electronic databases including PubMed, ScienceDirect and Google Scholar were used in this study. We had intended to perform a meta-analysis, but this was not possible due to variation in study design and reporting. The search strategy identified 1,410 articles through selected databases and 5 clinical trials met the inclusion criteria for quantitative synthesis. The quality assessment for risk of bias of the selected studies was evaluated by Cochrane risk of bias tool. The inclusion criteria were randomized controlled trials. We included participants with wounds regardless of age, gender, and ethnicity. The different types of wound are burn wound, diabetic foot ulcer, hypertrophic scar, split-thickness skin graft, and post laser resurfacing. 


Results: The favorable effect of C. asiatica was observed with a quicker wound healing, possibly due to the synthesis of collagen type 1, 2, and 3, stimulation of fibronectin, and remodeling of the extracellular matrix. Furthermore, C. asiatica has a beneficial effect on anti-inflammation and increases tensile strength, accelerating the formation of epithelium and keratin.


Conclusion: C. asiatica may have beneficial effects on wound healing; however, more clinical trials are needed in order to perform a meta-analysis to ensure the wound healing effects of the plant in different parameters.

Article Details

How to Cite
Hongsing, P. ., Areesuk, K. ., Atsalikon, N., Pitiwattanakulchai, R. ., & Wei, C. J. . (2022). C10. A Systematic Review of Randomized Controlled Trial on Efficacy of Centella asiatica for Wound Healing. Journal of Health Science and Alternative Medicine, 109–115. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthscialternmed/article/view/257756
Section
Original Article

References

Centella asiatica (Linnaeus) Urban in Martius [Internet]. Flora of China. 2022 [cited 2022]. Available from: http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200015478.

Chandrika UG, Prasad Kumarab PA. Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. Adv Food Nutr Res. 2015;76:125-57.

Gohil KJ, Patel JA, Gajjar AK. Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian J Pharm Sci. 2010;72(5):546-56.

Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine. 2000;7(5):427-48.

Maquart FX, Chastang F, Simeon A, Birembaut P, Gillery P, Wegrowski Y. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol. 1999;9(4):289-96.

Cesarone MR, Belcaro G, De Sanctis MT, Incandela L, Cacchio M, Bavera P, et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology. 2001;52 Suppl 2:S15-8.

Incandela L, Cesarone MR, Cacchio M, De Sanctis MT, Santavenere C, D'Auro MG, et al. Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. Angiology. 2001;52 Suppl 2:S9-13.

Gosain A, DiPietro LA. Aging and Wound Healing. World Journal of Surgery. 2004;28(3):321-6.

Thomas Hess C. Checklist for Factors Affecting Wound Healing. Advances in Skin & Wound Care. 2011;24(4).

Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol. 2007;25(1):19-25.

Hou Q, Li M, Lu YH, Liu DH, Li CC. Burn wound healing properties of asiaticoside and madecassoside. Exp Ther Med. 2016;12(3):1269-74.

Nganlasom J, Suttitum T, Jirakulsomchok D, Puapairoj A. Effects of Centella Asiatica Linn. and Garcinia Mangostana Linn. on The Healing of Dermal Wounds in Diabetic Rats. Srinagarind Medical Journal. 2013;23(4):402-7.

Kang MS, Park KC, Nam SM. A split-face study of moisturizer containing Centella asiatica extract after ablative fractional carbon dioxide laser resurfacing. Arch Aesthetic Plast Surg. 2021;27(2):56-60.

Jenwitheesuk K, Rojsanga P, Chowchuen B, Surakunprapha P. A Prospective Randomized, Controlled, Double-Blind Trial of the Efficacy Using Centella Cream for Scar Improvement. Evidence-Based Complementary and Alternative Medicine. 2018;2018:9525624.

Damkerngsuntorn W, Rerknimitr P, Panchaprateep R, Tangkijngamvong N, Kumtornrut C, Kerr SJ, et al. The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial. J Altern Complement Med. 2020;26(6):529-36.

Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013;30(1):46-9.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ : British Medical Journal. 2015;349:g7647.

Cochrane Handbook for Systematic Reviews of Interventions. 2nd Edition ed. Chichester (UK): John Wiley & Sons; 2019.

Kuo YS, Chien HF, Lu W. Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers. Evid Based Complement Alternat Med. 2012;2012:418679.

Saeidinia A, Keihanian F, Lashkari AP, Lahiji HG, Mobayyen M, Heidarzade A, et al. Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm. Medicine (Baltimore). 2017;96(9):e6168.

Surakunprapha P, Winaikosol K, Chowchuen B, Punyavong P, Jenwitheesuk K, Jenwitheesuk K. A Prospective Randomized Double-blind study of silicone gel plus Herbal Extracts Versus Placebo in Pre-sternal hypertrophic scar prevention and amelioration. Heliyon. 2020;6(5):e03883.

Chandrika UG, Prasad Kumara PAAS. Chapter Four - Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. In: Henry J, editor. Advances in Food and Nutrition Research. 76: Academic Press; 2015. p. 125-57.

Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology. 1999;65(1):1-11.

Rosen H, Blumenthal A, McCallum J. Effect of asiaticoside on wound healing in the rat. Proc Soc Exp Biol Med. 1967;125(1):279-80.

Comino-Sanz IM, López-Franco MD, Castro B, Pancorbo-Hidalgo PL. The Role of Antioxidants on Wound Healing: A Review of the Current Evidence. J Clin Med. 2021;10(16).

Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytotherapy Research. 1999;13(1):50-4.

Tang B, Zhu B, Liang Y, Bi L, Hu Z, Chen B, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. Archives of Dermatological Research. 2011;303(8):563-72.

Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothelial growth factor in wound healing. J Surg Res. 2009;153(2):347-58.

Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 1999;65(1):1-11.

Hashim P, Sidek H, Helan MH, Sabery A, Palanisamy UD, Ilham M. Triterpene composition and bioactivities of Centella asiatica. Molecules. 2011;16(2):1310-22.

Lichota A, Gwozdzinski L, Gwozdzinski K. Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. Eur J Med Chem. 2019;176:68-91.