C01. Analysis of the clinical therapeutic effect of Professor Wang Yue on 42 cases of Sjogren's syndrome overlaps with Hashimoto's thyroiditis

Abstract

Introduction: Clinical work and reports in the past ten years have found abnormal thyroid function in many patients with Sjögren's syndrome (SS), and Hashimoto's thyroiditis (HT) is the most common. Both are Autoimmune diseases, and there is currently no effective treatment. Traditional Chinese Medicine can effectively improve patients' clinical symptoms and laboratory indicators through syndrome differentiation, treatment, and holism modulating. 

Objective: To examine the TCM method of differentiation, treatment, medication characteristic, and clinical effect of Professor Wang Yue in treating primary Sjogren's syndrome overlap with Hashimoto's thyroiditis (SS-HT).

Methods: 42 cases with SS-HT from the outpatient department of Professor Wang Yue of Nanjing Affiliated Hospital of traditional Chinese medicine between January 2015 to August 2020 were selected. Excel 2010 was used to collect and frequency analysis the general data, syndrome types, and medication characteristics of Professor Wang Yue in treating SS-HT, and used SPSS 24.0 software to statistically analyzed the TCM syndrome score and laboratory index before and after treatment. 

Results: Professor Wang Yue mainly treated SS-HT by replenishing Qi and nourishing Yin, generating fluid and relieving thirst, clearing heat and purging fire, reducing swelling, and dispersing knots. Six cases were markedly effective, 15 cases were improved, 19 were effective, and two were ineffective. The total efficiency was 95.24%. After treatment, TCM syndrome score decreased significantly (P < 0.01), CRP, ESR, TGAb, TPOAb decreased significantly (P < 0.01).  

Conclusion: SS-HT's pathogenesis is Yin deficiency and internal heat in the first stage. In the middle stage is both Qi and Yin deficiency, and liver and kidney Yin deficiency are in the late stage. SS-HT treatment method moistens the lung and clears the stomach heat, replenishing Qi and Yin, tonifying the liver and kidney, and reducing swelling and dispersing knots. Chinese Medicine treatment of SS-HT has a definite curative effect: it can relieve clinical symptoms and reduce the inflammatory index and thyroid autoantibody without side effects, including anti-inflammatory, analgesic, anticoagulation, immune regulation, liver, and kidney protection. It is worthy of clinical application.