Arterial Stiffness and Cardiac Autonomic Function in Severe Obstructive Sleep Apnea Patients without Continuous Positive Airway Pressure

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Jirawat Wattanapanyawech


Background: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and contributes to increased morbidity and poor cardiovascular outcomes. It is one of the risk factors for cardiovascular disease.

Objective: This study aimed to determine the associations between sleep apnea parameters and arterial stiffness, cardiac autonomic function, and evaluate changes in arterial stiffness and cardiac autonomic function in patients with severe OSA without continuous positive airway pressure (CPAP) treatment.

Methods: Twenty severe OSA patients without CPAP treatment were recruited for this study. All participants underwent arterial stiffness evaluation by carotid-femoral pulse wave velocity (PWV) using a SphygmoCor device, and cardiac autonomic function by heart rate variability (HRV) measurement using LabChart-7. All participants were measured using these medical instruments at baseline on day 0, day 90, and day 180. Associations between sleep apnea parameters and HRV parameters were observed during the supine and tilt positions. The significance levels were set at a = 0.050 and 0.001, respectively.

Results: There was no significant association between sleep apnea parameters and PWV. HRV showed significant changes at day 90 (p-value < 0.001) and day 180 (p-value < 0.001). PWV increased significantly after day 180 without CPAP treatment.

Conclusions: This study revealed that sleep apnea indices are associated with cardiac autonomic function. OSA patients without CPAP treatment have deteriorated cardiac autonomic function in the supine and tilt positions and increased arterial stiffness after day 180.

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How to Cite
Wattanapanyawech, J. . (2020). Arterial Stiffness and Cardiac Autonomic Function in Severe Obstructive Sleep Apnea Patients without Continuous Positive Airway Pressure. Journal of Health Science and Alternative Medicine, 2(3), 16–21. Retrieved from
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