Mortality to Incidence ratio of Cholangiocarcinoma in Khon Kaen Province

Abstract

Cholangiocarcinoma (CCA) is a disease mostly found in the North-east region of Thailand. This area used to have the highest incidence in the world. However, a few studies on the incidence and mortality of CCA were found especially in the North-east region. Even, CCA is still an important issue and has unique characteristics related to liver fluke infection among people in this region. Objective to study the mortality to incidence ratio of CCA in Khon Kaen province. The retrospective cohort study using data from the Khon Kaen Population-Based Cancer Registry. The sample was patients who were diagnosed with CCA between 2017-2023. All patient was followed until 31^st December 2022. The Age-standardized rate (ASR), Age-standardized mortality rate (ASMR), and Mortality to Incidence ratio (M/I ratio) were calculated and we reported them with a 95% Confidence Interval. We reported the overall of ASR per 100,000 person-years among the Khon Kaen population was 16.2 for males (95% CI: 15.1 to 17.2) and 6.9 for females (95% CI: 6.3 to 7.6). The district with the highest ASR among males was Phra Yuen district (ASR = 29.2 per 100,000 person-years) and among females was Khao Suan Kwang district (ASR = 12.3 per 100,000 person-years). The ASMR among males was 9.3 per 100,000 person-years (95% CI: 8.5 to 10.1) and females was 4.2 per 100,000 person-years (95% CI: 3.7 to 4.7). The district with the highest ASMR among males was Wiang Kao district (ASMR = 28.8 per 100,000 person-years) and among females was Puei Noi district (ASMR = 16.0 per 100,000 people-years). The three districts that have more than 1 M/I ratio in Khon Kaen province, were Pue Noi, Chonnabot, and Wiang Kao (M/I ratio 1.33, 1.11, and 1.05, respectively) M/I ratio greater than 1 indicates incompleteness of the cancer registry and potential to diagnose cancer has decreased, they have been a low survival rate of patients. In conclusion, the incidence and mortality of CCA in Khon Kaen province was low. It is mostly found among the elderly and differs depending on the districts. The M/I ratio greater than 1 should review the completeness of their cancer registries, treatment guidelines for cholangiocarcinoma patients.