The Cost Effective Analysis of lifestyle Modification and Medication intervention to prevent the development of type 2 diabetes in prediabetes

Abstract

Assessment of cost effectiveness to prevent diabetes mellitus in prediabetes populations compared two interventions between lifestyle modification and metformin treatment by decision tree analysis model. The cost of providing services to prevent diabetes mellitus and the number of new diabetes mellitus patients occurred in each intervention was secondary data from systematic literature review in medical journal database.

Lifestyle modification that composed of received diabetes knowledge, dietary control and exercise was the most cost effectiveness intervention to prevent diabetes mellitus. Prevention of diabetes mellitus in the populations at risk 8,560 cases with cost of 5,872.6 US. dollars for lifestyle modification and 7,830 cases with cost of 8,456.06 US. dollars for metformin treatment. By using sensitivity analysis, if the cost of lifestyle modification was more than 72,000 US. dollars then metformin treatment was the most cost effectiveness intervention.

          This study presented public health aspects of pre-diabetes populations as a whole. metformin treatment may be necessary in high risk patients with family history of diabetes mellitus and high Body Mass Index significantly. So, we need study that compare cost effectiveness between lifestyle modification with and without metformin treatment for policy advocacy to prevent diabetes mellitus in high risk populations.