Immune Response to Diphtheria Booster Vaccine in Adult in Thailand

Abstract

A cross sectional descriptive study was done to measure the antibody response to diphtheria after two booster doses of diphtheria  vaccine. Areas were purposived selected after post outbreak response immunization. We used multi- stage stratified and simple random sampling. Total of 374 participants age 15 years and older were included and collect serum 3-5ml. of each. Within these, 196 and 178 participants were in the first and second dose booster group respectively. Diphtheria antibody level were tested after 3-6 weeks post vaccination in each group. Results revealed that single dose booster of diphtheria  vaccine give long term immunity level by 95 percent in adult population.