Efficiency of Cholangiocarcinoma Detection in High Risk Populations of Phonthong district Roi-et Province according to the Cholangiocarcinoma Screening and Care Program (CASCAP)

Abstract

This prospective analytical study aimed to study efficiency of cholangiocarcinoma detection in 1,000 High Risk Populations of Phonthong district Roi-et Province according to CASCAP.The result showed rate of subjects who required further testing after screening was 2% (20/1,000). Ten of the 20 subjects with a positive sonographic screening study had abdominal cancers detected on further investigation. One subject had false negative result. The positive predictive value of screening was 50% (10/20), and the rate of screening detection cancer was 1.0% (10/1,000). The prevalence of abdominal cancers was 1.1% (11/1,000), the sensitivity of screening for detection of abdominal cancers was 90.91% (10/11), and the specificity was 98.99% (979/989). CCA was suspected in 8 patients (2 cases of suspicious early cholangiocarcinoma and 1 case of refuse appropriate treatment), and 4/5 cases (80%) were at a curative resectable stage.             Cholangiocarcinoma detection in High Risk Populations of Phonthong district Roi-et Province according to CASCAP projectis effective because it has a relatively high sensitivity and can lead to premalignant lesions and early stage cholangiocarcinoma, resulting in improved patient outcomes.