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This study is an analytical Hospital-based case-control study. Aimed of this study was to predict the equations used for risk factor of oral cancer in the Northeast. This study investigated oral cancers in the incidence cases that were diagnosed by physicians in outpatients of Otolaryngology Department. The patients were confirmed that they had the oral cancers by histological confirmed from the laboratory during 2010-2014. Case subjects, 104 were came from the 3 hospitals (Srinagarind Hospital-Khon Kaen University teaching hospital, Khon Kaen Regional Hospital, and Sappasitthiprasong Hospital). The control group was patients who had ear, nose and throat diseases liked flu, snoring, allergy, and sudden hearing loss. These diseases were not related to oral cancer and human papillomavirus (HPV). According to the study, the results indicated that the variables were related to incidence of oral cancer and a prediction equation for oral cancer by a multiple logistic regression as follows: the logit (oral cancer) =2.47 (Cigarette smoking) + 3.81(Betel quid chewing).Moreover, results also showed that the prediction ability of this equation from the area under ROC curve; AUC is able to predict the occurrence of oral cancer up to 73.74% at the intersection point of 1 with the sensitivity of 87.50% and the specificity of 53.83%. When test was positive, accuracy of the prediction was 65.47%. In contrast, when test was negative, accuracy of the prediction was 81.16%. Precision of the prediction was 70.67%. Thus, equations and results of test, the study found that in the cigarette smoking and betel quid chewing were found the most important factors than all the factors that are associated with oral cancer. This study can be applied in the assessment of the occurrence for oral cancer more precisely. The study also found guidelines to develop the prevention and the treatment of the oral cancer in the future to be more effectiveness.
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บทความที่ลงพิมพ์ในวารสารสำนักงานป้องกันควบคุมโรคที่ 7 ขอนแก่น ถือเป็นผลงานทางวิชาการหรือวิจัย และวิเคราะห์ตลอดจนเป็นความเห็นส่วนตัวของผู้เขียน ไม่ใช่ความเห็นของวารสารสำนักงาน ป้องกันควบคุมโรคที่ 7 จังหวัดขอนแก่น หรือ ของกองบรรณาธิการแต่ประการใด ผู้เขียนต้องรับผิดชอบต่อบทความของตนเอง
2. National cancer institute. Surveillance,
epidemiology, and end results program [Internet].2010 [cited 2010 July 5]. Available from: https://
3. Khuhaprema T, Srivatanakul P, Sriplung H,Wiangnon S, Sumitsawan Y, Attasara P. Cancer
in Thailand (2001-2003) Vol.V. J Nati cancer Inst 2010;5: 11-5.
4. Attasara P, Buasom R. Hospital-based Cancer Registries, Thailand 2009. Bangkok: National Cancer Institute department of Medical servicesMinistry of Public Health; 2010.
5. Kulchaya Loyha, Patravoot Vatanasapt, Supannee Promthet, Donald Maxwell Parkin. Risk factors
for oral cancer in Northeast Thailand. Asian pac J cancer Prev. Prev; 2012; 13(10): 5087–90.
6. James JS. Case-Control Studies: Design, Conduct, Analysis. Front Cover. Oxford University Press;1982: 368.
7. Madani AH, Jahromi AS, Madhurima Dikshit,Debanshu Bhaduri. Risk assessment of tobacco types and oral cancer. Am J Pharm Toxicol. 2010;5(1): 9-13.
8. Applebaum KM, Furniss CS, Zeka A, Posner MR,Smith JF, Bryan J, et al. Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Nati Cancer Inst 2007; 99(3):1801–10.
9. Boccia S, Cadoni G, Sayed-Tabatabaei FA,Volante M, Arzani D, De Lauretis A, et al. CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1exons 3 and 4, and NAT2 polymorphisms,smoking,consumption of alcohol and fruit and vegetables
and risk of head and neck cancer. J Cancer Res ClinOncol 2008; 134(1):93–100.
10. Chatterjee S, Dhar S, Sengupta B, Ghosh A, DeM, Roy S, et al. Cytogenetic monitoring in humanoral cancers and other oral pathology: themicronucleus test in exfoliated buccal cells.Toxicol Mech Methods 2009;19(6-7):427-3
11. D’Souza G, Kreimer AR, Viscidi R, PawlitaM,Fakhry C,Koch WM,et al. Case–control studyof human papillomavirus and oropharyngealcancer. N Engl J Med 2007;356:1944-56.
12. Parkin DM, Pisani P, Ferlay J. Estimates of theworldwide incidence of 25 major cancers in 1990.Int J Cancer 1999;80:827–41.
13. Simarak S, De Jong UW, Breslow N, Dahl CJ,Ruckphaopunt K, Scheelings P, et al. Cancerof oral cavity, pharynx/larynx and lung in northThailand: case--control study and analysis of cigar smoke. Br J Cancer 1977; 130-40.
14. Vatanasapt V, Sriamporn S, MacLennan R. Contrasts in risk factors for cancers of the oral cavity and hypopharynx and larynx in Khon Kaen, Thailand. In: Varma AK, editor. Oral Oncology.Vol. II: Proceedings of the International Congresson Oral Cancer. New Delhi: Macmillan India;1991.