Residual Monomer from Dental Adhesive: A Review of the Literature
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Abstract
Recently, resin composite and dental adhesive are renowned for apply in restorative treatment because of advantage in esthetics and superior benefits. The key component dental adhesive is resin monomer such as Bis-phenol-A-diglycidyl-methacrylate (Bis-GMA) , and Hydroxyethyl methacrylate (HEMA). Those materials are not fully polymerized due to various factors. Therefore, residual monomers can be eluted from restorative materials. Amount and rate of elution depend on their chemical properties. In clinical situation, patients can receive or contact residual monomers by several routes for example receive via oral cavity or penetrate to dental pulp. Also, resin monomer with low molecular weight and hydrophilic type can easily diffuse through dentine barrier. From in vitro studies, unreacted resin monomers have evident toxicity to dental pulp cells by depletion of glutathione and its substrate. However, substantial amount and prolonged exposure time could potentially induce pulp cell apoptosis through these mechanisms.
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References
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