Incidence, Severity, and Risk Factors of Oral Mucositis in Adult and Elderly Cancer Patients after Receive Chemotherapy in Uttaradit Hospital
Article Sidebar
Main Article Content
Abstract
Objectives: This study is a prospective cohort study investigated incidence and severity in adult and elderly cancer patient who have received chemotherapy in Uttaradit Hospital.
Materials and Methods: A sample from 61 patients with ongoing cancer treatment. Tree cycles of treatment had been followed or until the mucositis had developed. Data select from demographic questionnaire, MNA and sample were examined by World Health Organization (WHO 1979) mucositis scale. The results were analyzed using descriptive statistics chi-square tests and Kruskal-Wallis test.
Results: Incidence rate of oral mucositis was 90.16% among our samples. The most common in severity grade 1 43(70.5%), buccal mucosa 37(67.27%). Common characteristics included female, Gastrointestinal cancers, patient that prone to malnutrition and patient with cardiovascular disease.
Conclusions: incidence and severity of elderly more than adult. So, should be oral examination, closely monitored and follow up. Geriatric Dentistry should become into the oncological working group to focus on preventing and managing oral mucositis.
Article Details
References
Kanaungnit P. Cancer concept and Cancer prevention. In: Wandee T, ed: Medical Nursing No.1, Vol 5. Bangkok: NP-Place; 2018: 142-168 (in Thai).
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J clin 2018; 68(6): 394-424.
www.nci.go.th [URL of database on the Internet]. Bangkok: Hospital-based cancer registry; 2018 [cited 2020 March 20]. Available from: http://www.nci.go.th/th/File_download/Nci%20Cancer%20Registry/
Hospital%20Based_2018.pdf
Scully C, Sonis S, Diz PD. Oral mucositis. Oral Dis 2006; 12(3): 229-241.
Mercadante S, Aielli F, Adile C, et al. Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients. Support Care Cancer 2015; 23(11): 3249-3255.
Çakmak S, Nural N. Incidence of and risk factors for development of oral mucositis in outpatients undergoing cancer chemotherapy. Int J Nurs Pract 2019; 25(1): e12710.
Al Ibraheemi AA, Shamoun S. Incidence and risk factors of oral mucositis in patients with breast cancer who receiving chemotherapy in Al-Bashir hospital. Int J Hematol Oncol Stem Cell Res 2016; 10(4): 217-223.
Pico JL, Avila-Garavito A, Naccache P. Mucositis: its occurrence, consequences, and treatment in the oncology setting. Oncologist 1998; 3(6): 446-451.
Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol 2003; 39(2): 91-100.
Parkhill AL. Oral mucositis and stomatitis associated with conventional and targeted anticancer therapy. J Parmacovigilance 2013; 1(4): 1-4.
van Abbema DL, van den Akker M, Janssen-Heijnen ML, et al. Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer: A systematic review. J Geriatr Oncol 2019; 10(1): 31-41.
Ito S, Ito H, Sato N, et al. Clinical factors associated with the therapeutic outcome of chemotherapy in very elderly cancer patients. Int J Clin Oncol 2019; 24(5): 596-601.
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977; 33(1): 159-174.
www.mna-elderly.com. [URL of homepage on the Internet] La Tour-de-Peilz, Switzerland: Nestlé Nutrition Institute; 2006 [cited 2020 April 20]. Available from: https://www.mna-elderly.com/forms/mini/mna_mini_thai.pdf
World Health Organization. Handbook for reporting results of cancer treatment. Geneva, Switzerland: World Health Organization; 1979 [cited 2020 April 20]. Available from: https://apps.who.int/iris/bitstream/handle/10665/37200/WHO_OFFSET_48.pdf?sequence=1&isAllowed=y
Maria OM, Eliopoulos N, Muanza T. Radiation-induced oral mucositis. Front Oncol 2017; 7: 89.
Bragalone DL. Drug information handbook for oncology. 16th ed. Ohio: Lexicomp; 2019: 2175-2435.
El Osta N, El Osta L, Lassauzay C, Ghosn M, Tubert-Jeannin S, Hennequin M. Oral health and chemotherapy act as cofactors in malnutrition in the elderly with other cancers than head and neck malignancies. Clin Oral Invest 2019; 23(1): 235-243.
Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer. Dent Clin North Am 2008; 52(1): 61–77.
Sonis ST, Elting LS, Keefe D, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 2004; 100(S9): 1995-2025.
Cidon EU. Chemotherapy induced oral mucositis: prevention is possible. Chin Clin Oncol 2018; 7(1): 6.
Chen SC, Lai YH, Huang BS, Lin CY, Fan KH, Chang JTC. Changes and predictors of radiation-induced oral mucositis in patients with oral cavity cancer during active treatment. Eur J Oncol Nurs 2015; 19(3): 214-219.
Libik TV, Gileva OS, Danilov KV, Grigorev SS, Pozdnyakova AA. Management of cancer therapy-induced oral mucositis pain and xerostomia with extra-and intra oral laser irradiation. AIP Conference Proceedings. 2017, AIP Publishing LLC.
Pradubpet K, Busaba S. The Incidence of mucositis among cancer patients receiving continuous 5-fluorouracil at least 4 hours. GRC [serial on the Internet]. 2013 [cited 2020 May 8];14: [about 11 p.]. Available from: https://gsbooks.gs.kku.ac.th/56/grc14/files/mmo8.pdf (in Thai).
Nishimura N, Nakano K, Ueda K, et al. Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas. Support Care Cancer 2012; 20(9): 2053-2059.
Carreón-Burciaga RG, Castañeda-Castaneira E, González-González R, Molina-Frechero N, Gaona E, Bologna-Molina R. Severity of oral mucositis in children following chemotherapy and radiotherapy and its implications at a single oncology centre in Durango state, Mexico. Int J Pediatr 2018. [serial on the Internet]. 2018 [cited 2018 Dec 12]; 2018(3252765): [about 5 p.]. Available from: https://doi.org/10.1155/2018/3252765
Antonacci G, Cerati C, Pancheri L, et al. A prospective observational study of oral mucositis in oncology patients receiving cancer therapy. Ann Oncol 2015; 26: vi113 (Abstr M23).
Villa A, Sonis ST. Mucositis: pathobiology and management. Curr Opin Oncol 2015; 27(3): 159-164.
Sonis ST. Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 2009; 45(12): 1015-1020.
Ribeiro SB, de Araujo AA, de Araujo Junior RF, et al. Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters. PloS One 2017; 12(10): e0186511
Lalla RV, Latortue MC, Hong CH, et al. A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer 2010; 18(8): 985–992.
Gandhi K, Datta G, Ahuja S, Saxena T, G Datta A. Prevalence of oral complications occurring in a population of pediatric cancer patients receiving chemotherapy. Int J Clin Pediatr Dent 2017; 10(2): 166-171.
Wilberg P, Hjermstad MJ, Ottesen S, et al. Chemotherapy-associated oral sequelae in patients with cancers outside the head and neck region. J Pain Symptom Manage 2014; 48(6): 1060-1069.
Mosel DD, Bauer RL, Lynch DP, Hwang ST. Oral complications in the treatment of cancer patients. Oral Dis 2011; 17(6): 550–559.
Chaveli-López B, Bagán-Sebastián JV. Treatment of oral mucositis due to chemotherapy. J Clin Exp Dent 2016; 8(2): e201-209.
Lalla RV, Bowen J, Barasch A, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2014; 120(10): 1453-1461.
Carvalho CG, Medeiros-Filho JB, Ferreira MC. Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence. Support Care Cancer 2018; 26(8): 2651-2661.