The Use of Probiotics for Caries Prevention

Main Article Content

Onnida Wattanarat

Abstract

Probiotics are recognized to be the additional preventive strategies against dental caries. This article aims to review etiology and prevention of dental caries, fundamental knowledge of probiotics and probiotic effects for caries prevention. Most clinical trials have shown the probiotic ability to reduce mutans streptococci (MS) counts, but this
effect is variable and short-lasting. Only a small number of studies have so far investigated the prevention of caries increment or caries occurrence as a real efficient endpoint. Although positive findings of probiotic supplements for caries prevention are promising, further long-term clinical trials with caries outcomes are needed before clinical application can be made.

Article Details

How to Cite
Wattanarat, O. . (2017). The Use of Probiotics for Caries Prevention. Chiang Mai Dental Journal, 38(2), 39–51. Retrieved from https://he01.tci-thaijo.org/index.php/cmdj/article/view/210643
Section
Review article

References

Petersen PE, Ogawa H. Prevention of dental caries through the use of fluoride--the WHO approach. Community Dent Health 2016; 33(2): 66-68.

สำนักทันตสาธารณสุข, กรมอนามัย, กระทรวงสาธารณสุข. รายงานผลการสำรวจ สภาวะสุขภาพช่องปากระดับประเทศ ครั้งที่ 7 ประเทศไทย พ.ศ. 2555. พิมพ์ครั้งที่ 1. กรุงเทพมหานคร: สำนักงานกิจการโรงพิมพ์องค์การสงเคราะห์ทหารผ่านศึก; 2556: 13-15.

Featherstone JD, Duncan JF, Cutress TW. A mechanism for dental caries based on chemical processes and diffusion phenomena during in-vitro caries simulation on human tooth enamel. Arch Oral Biol 1979; 24: 101-112.

Fejerskov O. Changing paradigms in concepts on dental caries: consequences for oral health care. Caries Res 2004; 38: 182-191.

Kidd EAM, Fejerskov O. What constitutes dental caries? Histopathology of carious enamel and dentin related to the action of cariogenic biofilms. J Dent Res 2004; 83: 35-38.

Fejerskov O, Nyvad B, Kidd EAM. Dental caries: the disease and its clinical management. 3rd ed. Copenhagen: Blackwell Monksgaard; 2015.

Sansone C, Van Houte J, Joshipura K, Kent R, Margolis HC. The association of mutans streptococci and non-mutans streptococci capable of acidogenesis at a low pH with dental caries on enamel and root surfaces. J Dent Res 1993; 72: 508-516.

Van Houte J. Role of micro-organisms in caries etiology. J Dent Res 1994; 73: 672-681.

Caufield PW. Dental caries--a transmissible and infectious disease revisited: A position paper. Pediatr Dent 1997; 19: 491-498.

Tanzer JM, Livingston J, Thompson AM. The microbiology of primary dental caries in humans. J Dent Educ 2001; 65: 1028-1037.

Kuramitsu HK. Virulence properties of oral bacteria: Impact of molecular biology. Curr Issues Mol Biol 2001; 3: 35-36.

Banas JA. Virulence properties of Streptococcus mutans. Front Biosci 2004; 9: 1267-1277.

Tinanoff N, Kanellis MJ, Vargas CM. Current understanding of the epidemiology mechanisms, and prevention of dental caries in preschool children. Pediatr Dent 2002; 24: 543-551.

WHO/FAO. Guidelines for the evaluation of probiotics in food. Ontario: 2002 [cited 2015 May 3]. Available from: ftp://ftp.fao.org/es/esn/food/wgreport2.pdf

Meurman JH. Probiotics: Do they have a role in oral medicine and dentistry? Eur J Oral Sci 2005; 113: 188-196.

Twetman S, Stecksen-Blicks C. Probiotics and oral health effects in children. Int J Paediatr Dent 2008; 18: 3-10.

Penders J, Thijs C, Vink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006; 118: 511-521.

Kononen E, Kanervo A, Takala A, Asikainen S, Jousimies-Somer H. Establishment of oral anaerobes during the first year of life. J Dent Res 1999; 78: 1634-1639.

Nase L, Hatakka K, Savilahti E, et al. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 2001; 35: 412-420.

Ahola AJ, Yli-Knuuttila H, Suomalainen T, et al. Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors. Arch Oral Biol 2002; 47: 799–804.

Nikawa H, Makihira S, Fukushima H, Nishimura H, Ozaki Y, Ishida K, et al. Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci. Int J Food Microbiol 2004; 95(2): 219–23.

Montalto M, Vastola M, Marigo L, et al. Probiotic treatment increases salivary counts of lactobacilli: A double-blind, randomized, controlled study. Digestion 2004; 69: 53–56.

Caglar E, Cildir SK, Ergeneli S, Sandalli N, Twetman S. Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets. Acta Odontol Scand 2006; 64: 314-318.

Caglar E, Kavaloglu SC, Kuscu OO, Sandalli N, Holgerson PL, Twetman S. Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli. Clin Oral Investig 2007; 11: 425-429.

Caglar E, Kuscu OO, Cildir SK, Kuvvetli SS, Sandalli N. A probiotic lozenge administered medical device and its effect on salivary mutans streptococci and lactobacilli. Int J Paediatr Dent 2008; 18: 35–39.

Stecksen-Blicks C, Sjostrom I, Twetman S. Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: A cluster-randomized study. Caries Res 2009; 43: 374-381.

Lexner MO, Blomqvist S, Dahlen G, Twetman S. Microbiological profiles in saliva and supragingival plaque from caries-active adolescents before and after a short-term daily intake of milk supplemented with probiotic bacteria - a pilot study. Oral Health Prev Dent 2010; 8: 383-388.

Petersson LG, Magnusson K, Hakestam U, Baigi A, Twetman S. Reversal of primary root caries lesions after daily intake of milk supplemented with fluoride and probiotic lactobacilli in older adults. Acta Odontol Scand 2011; 69: 321–327.

Aminabadi N.A, Erfanparast L, Ebrahimi A, Oskouei SG. Effect of chlorhexidine pretreatment on the stability of salivary lactobacilli probiotic in six- to twelve-year-old children: A randomized controlled trial. Caries Res. 2011; 45: 148–154.

Jindal G, Pandey RK, Agarwal J, Singh M. A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children. Eur Arch Paediatr Dent 2011; 12: 211–215.

Chuang LC, Huang CS, Ou-Yang LW, Lin SY. Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora. Clin Oral Investig 2011; 15: 471-476.

Singh RP, Damle SG, Chawla A. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis BB12 and Lactobacillus acidophilus LA5. Acta Odontol Scand 2011; 69: 389–394.

Marttinen A, Haukioja A, Karjalainen S, et al. Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque. Clin Oral Investig 2012; 16: 797–803.

Juneja A, Kakade A. Evaluating the effect of probiotic containing milk on salivary mutans streptococci levels. J Clin Pediatr Dent 2012; 37: 9–14.

Keller MK, Twetman S. Acid production in dental plaque after exposure to probiotic bacteria. BMC Oral Health 2012; 12: 44.

Campus G, Cocco F, Carta G, et al. Effect of a daily dose of Lactobacillus brevis CD2 lozenges in high caries risk schoolchildren. Clin Oral Investig 2013; doi:10.100.7/s00784-013-09-80-9.

Hasslof P, West CE, Karlsson VF, Brandelius C, Stecksen-Blicks C. Early intervention with probiotic Lactobacillus paracasei F19 has no long-term effect on caries experience. Caries Res 2013; 47: 559-565.

Stensson M, Koch G, Coric S, et al. Oral administration of Lactobacillus reuteri during the first year of life reduces caries prevalence in the primary dentition at 9 years of age. Caries Res 2014; 48: 111-117.

Teanpaisan R, Piwat S. Lactobacillus paracasei SD1, a novel probiotic, reduces mutans streptococci in human volunteers: a randomized placebo-controlled trial. Clin Oral Investig 2014; 18(3): 857–62.

Ritthagol W, Saetang C, Teanpaisan R. Effect of Probiotics containing Lactobacillus paracasei SD1 on salivary mutans streptococci and lactobacilli in orthodontic cleft patients: a double-blinded, randomized, placebo-controlled study. Cleft Palate Craniofac J 2014; 51(3): 257-63.

Wattanarat O, Makeudom A, Sastraruji T, et al. Enhancement of salivary human neutrophil peptide 1-3 levels by probiotic supplementation. BMC Oral Health 2015; 15(1): 19. doi: 10.1186/s12903-015-0003-0.

Teanpaisan R, Piwat S, Tianviwat S, Sophatha B, Kampoo T. Effect of long-term consumption of Lactobacillus paracasei SD1 on reducing mutans streptococci and Caries Risk: a randomized placebo-controlled trial. Dent J 2015; 3(2): 43-54.

Rodriguez G, Ruiz B, Faleiros S, Vistoso A, Marro ML, Sanchez J, Urzua I, Cabello R. Probiotic compared with standard milk for high-caries children: A cluster randomized trial. J Dent Res 2016; 95: 402-407.

Caglar E, Sandalli N, Twetman S, Kavaloglu S, Ergeneli S, Selvi S. Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults. Acta Odontol Scand 2005; 63: 317-320.

Caglar E, Kuscu OO, Kuvvetli S, Cildir S, Sandalli N, Twetman S. Short-term effect of ice-cream containing Bifidobacterium lactis BB-12 on the number of salivary mutans streptococci and lactobacilli. Acta Odontol Scand 2008; 66: 154–158.

Cildir SK, Germec D, Sandalli N, et al. Reduction of salivary mutans streptococci in orthodontic patients during daily consumption of yoghurt containing probiotic bacteria. Eur J Orthod 2009; 31: 407–411.

Taipale T, Pienihakkinen K, Alanen P, Jokela J, Soderling E. Administration of Bifidobacterium animalis subsp. lactis BB-12 in early childhood: A post-trial effect on caries occurrence at four years of age. Caries Res 2013; 47: 364-372.

Hedayati-Hajikand T, Lundberg U, Eldh C, Twetman S. Effect of probiotic chewing tablets on early childhood caries-a randomized controlled trial. BMC Oral Health 2015; 15: 112 doi: 10.1186/s12903-015-0096-5.

Silva M, Jacobus NV, Deneke C, Gorbach SL. Antimicrobial substance from a human lactobacillus strain. Antimicrob Agents Chemother 1987; 31: 1231-1233.

Teanpaisan R, Piwat S, Dahlen G. Inhibitory effect of oral lactobacillus against oral pathogens. Lett Appl Microbiol 2011; 53: 452-459.

Piwat S, Teanpaisan R, Dahlen G, Thitasomakul S, Douglas CW. Acid production and growth by oral lactobacillus species in vitro. J Investig Clin Dent 2012; 3: 56-61.

Piwat S, Sophatha B, Teanpaisan R. An assessment of adhesion, aggregation, and surface charges of Lactobacillus strains derived from the human oral cavity. Lett Appl Microbiol 2015; 24: doi: 10.1111/lam.12434.

Levine RS. Milk, flavoured milk products and caries. Br Dent J 2001; 191: 20.

Teanpaisan R, Chooruk A, Wannun A, Wichienchot S, Piwat S. Survival rates of human-derived probiotic Lactobacillus paracasei SD1 in milk powder using spray drying. Songklanakarin J Sci Tech 2012; 34 (3): 241-245.

Ishibashi, N, Shimamura S. Bifidobacteria: research and development in Japan. Food Technol 1993; 46: 126-135.

Cabana MD, Shane AL, Chao C, Oliva-Hemker M. Probiotics in primary care pediatrics. Clin Pediatr (Phila) 2006; 45: 405-410.

Meurman JH, Stamatova I. Probiotics: contributions to oral health. Oral Dis 2007; 13 (5): 443-451.

Minelli EB, Benini A. Relationship between number of bacteria and their probiotic effects. Microb Eco in Health and Dis 2008; 20: 180-183.

Banas JA, Popp ET. Recovery of viable bacteria from probiotic products that target oral health. Probiotics Antimicrob Proteins 2013; 5 (3): 227-231.

Ouwehand AC. A review of dose-responses of probiotics in human studies. Benef Microbes 2016; 23: 1-10. doi: 10.3920/BM2016.0140.

Guandalini S, Pensabene L, Zikri MA, et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: A multicenter european trial. J Pediatr Gastroenterol Nutr 2000; 30: 54-60.

Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001; 107: 129-134.

Madden JAJ, Hunter JO. A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr 2002; 88: S67–S72.

Hoveyda N, Heneghan C, Mahtani KR, Perera R, Roberts N, Glasziou P. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol 2009; 9: 15. doi: 10.1186/1471-230X-9-15.

Reid G, Burton J, Hammond JA, Bruce AW. Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli. J Med Food 2004; 7: 223-228.

Falagas M, Betsi GI, Athanasiou S. Probiotics for the treatment of woman with bacterial vaginosis. Clin Microbiol Infect 2007; 13(7): 657-664.

Husni RN, Gordon SM, Washington JA, Longworth DL. Lactobacillus bacteremia and endocarditis: Review of 45 cases. Clin Infect Dis 1997; 25: 1048-1055.

Hempel S, Newberry S, Ruelaz A, et al. Safety of probiotics used to reduce risk and prevent or treat disease. Evid Rep Technol Assess (Full Rep) 2011: 1-645.

Bonecker M, Grossman E, Cleaton-Jones PE, Parak R. Clinical, histological and microbiological study of hand-excavated carious dentine in extracted permanent teeth. SADJ 2003; 58: 273-278.

Krasse P, Carlsson B, Dahl C, Paulsson A, Nilsson A, Sinkiewicz G. Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri. Swed Dent J 2006; 30: 55-60.

Hatakka K, Ahola AJ, Yli-Knuuttila H, et al. Probiotics reduce the prevalence of oral candida in the elderly--a randomized controlled trial. J Dent Res 2007; 86: 125-130.

Burton JP, Chilcott CN, Tagg JR. The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics. Oral Dis 2005; 11 Suppl 1: 29-31.

Twetman S, Keller MK. Probiotics for caries prevention and control. Adv Dent Res 2012; 24: 98-102.

Cagetti MG, Mastroberardino S, Milia E, Cocco F, Lingstrom P, Campus G. The use of probiotic strains in caries prevention: A systematic review. Nutrients 2013; 5: 2530-2550.

Pitts N. "ICDAS"--an international system for caries detection and assessment being developed to facilitate caries epidemiology, research and appropriate clinical management. Community Dent Health 2004; 21: 193-198.

Jorgensen MR, Castiblanco G, Twetman S, Keller MK. Prevention of caries with probiotic bacteria during early childhood. Promising but inconsistent findings. Am J Dent 2016; 29: 127-131.

Yli-Knuuttila H, Snall J, Kari K, Meurman JH. Colonization of Lactobacillus rhamnosus GG in the oral cavity. Oral Microbiol Immunol 2006; 21: 129-131.