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Antibody against ABO blood group have been called naturally occurring antibody or regular antibody or expected antibody while other blood group system shows an unexpected antibody which is composed of alloantibody and autoantibody. Alloantibody does not respond against person’s red blood cells antigens. On the other hand, autoantibody does recognize red blood cells antigens. Antibody screening and identification are the main procedure before blood transfusion due to immediate or delayed hemolytic transfusion reactions (HTR) from antibody. Moreover, they are the cause of hemolytic disease of the fetus and newborn (HDFN) and shorter self-life of red blood cells. Plasma or serum including of single high-titer antibody shows benefits in the production of blood group typing reagents. Especially, B lymphocytes secret single antibody to make benefits in production of human monoclonal hybridoma for rare blood group reagents. This article need to compile many antibody screening and antibody to identify methods and exemplify interesting study reports of antibody screening and identification by using different methods of choice of medical scientist and medical technologists. Moreover, it will help them choose suitable methods and have some idea about how to make benefits from antibody in plasma and B lymphocytes secret antibody.