Hormone receptor status and clinical characteristics of breast cancer patients at Makarak Hospital: A retrospective observational study

Abstract

Background: Breast cancer patients with tumors that are estrogen receptor (ER)-positive and/or progesterone receptor (PR)-positive have lower risks of mortality after their diagnosis compared to women with ER- and/or PR-negative disease. However, few studies have evaluated variations in the prevalence and mortality risks of ER-/PR- tumors in Thai population.

Objective: To describe hormonal receptor status and clinical characteristics of breast cancer patients at Makarak Hospital, Thailand.

Methods: Medical records of patients of Makarak Hospital, 121 women who were at least 18 years old with primary diagnosis of invasive breast carcinoma from 2012 to 2016 regarding ICD10-TM and pathological report were reviewed. Hormone receptor status and clinical characteristics including age of diagnosis, year of diagnosis, histologic tumor type, stage, grade, size, and axillary lymph node status were evaluated.

Results: Average age at diagnosis of the patients were 52.4  12.4 years. Invasive ductal carcinoma was the most common tumor type in this population (95.9%). Among the identified cohort of 121 women, 87 (72.7%) women were known joint ER/PR receptor status. Forty-four cases had ER+/PR+ tumors (50.6%). Of the remaining women, 3 cases had ER+/PR- tumors (3.4%); 1 had ER-/PR+ tumors (1.1%); and, 39 had ER-/PR- tumors (44.8%).

Conclusion: Higher prevalence of ER-/PR- tumors were found in this study. Further researches are needed to examine factors related to and specific mortality risk of ER-/PRtumors in this population.