ศึกษาความสัมพันธ์ระหว่างดัชนีการสร้างเรติคิวโลไซต์กับภาวะพร่องเอนไซม์ G-6- PD ในทารกแรกเกิด โรงพยาบาลสระบุรี

Abstract

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a common hereditary enzymatic disorder in red blood cells, characterized by a significantly high prevalence in Thailand. This condition often leads to a pronounced increase in enzyme deficiency and is a contributing factor to neonatal jaundice. In severe cases, it can result in neonatal jaundice-associated brain damage and acute hemolysis due to rapid red blood cell breakdown. The main objective of this study was to investigate the correlation between the reticulocyte production index (RPI) and G-6-PD deficiency. Additionally, the study aimed to assess the occurrence of G-6-PD deficiency among newborns at Saraburi Hospital.The study involved analyzing G-6-PD enzyme levels using the careSTART G6PD Biosensor Analyzer on blood samples from 295 newborns. These samples were collected for analysis at the hospital's hematology and clinical chemistry laboratories. The results indicated that there was no statistically significant difference in RPI between the G-6-PD deficient group and the G-6-PD normal group (p-value < 0.05). Similarly, the study found significant differences in Hemoglobin (Hb) and Hematocrit (Hct) levels (p-value < 0.05).The prevalence of G-6-PD deficiency was found to be 15.25% in males, 77.78% in females among the deficient group, while the normal group exhibited 84.75% in males and 47.60% in females. The analysis of Hemoglobin, Hematocrit, and RPI values (expressed as Mean, Standard Deviation, and Min-Max) for both groups showed that RPI values greater than 3% in the G-6-PD deficient group indicated compensatory reticulocyte production to replace lost red blood cells. Furthermore, the male-to-female ratio within the G-6-PD deficient group was found to be 3.5 to 1.