Clinical Outcomes of Probiotic Lactobacillus Rhamnosus SD11 Supplementation for Dental Caries Prevention in Young Children: A Randomized Controlled Trial
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Abstract
Objective: The objective of this double-blind randomized controlled trial was to assess the effect of the probiotic L. rhamnosus SD11 on salivary mutans streptococci and lactobacilli counts, and on dental caries in young children. The potential side effects and the persistence of this probiotic were also observed.
Materials and Methods: One hundred children aged 2 to 5 years were allocated into two groups: the probiotic group received milk powder containing 107 CFU/g of L. rhamnosus SD11, while the control group received standard milk powder. Three grams of milk powder were provided daily for 3 months. Compliance and side effects were recorded daily. Salivary mutans streptococci and lactobacilli counts were assessed at baseline, 3 months, and 6 months. Dental caries examination was conducted at baseline and at 6 months.
Results: The findings indicated a statistically significant reduction in salivary mutans streptococci in the probiotic group at both 3 and 6 months (p<0.01). However, no significant difference in lactobacilli counts was observed between the two groups. At 6 months, a significantly lower caries progression (p=0.036) was found in the probiotic group (3.48%) compared to the control group (4.55%). Additionally, the presence of the probiotic strain was noted in 11.11% of the children. No adverse effects were reported in either group.
Conclusion: The use of probiotic L. rhamnosus SD11 could be considered an option for reducing caries progression and preventing the occurrence of new cavities in young children.
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บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการลงตีพิมพ์ในวิทยาสารทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่นถือเป็นลิขสิทธิ์เฉพาะของคณะทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่น หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใด ๆ จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษร จากคณะทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่นก่อนเท่านั้น
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