Prevalence of Sodium Lauryl Sulfate Allergy and Association of Patch Testing of Sodium Lauryl Sulfate Allergy and Self-Reported Recurrent Aphthous Stomatitis in Thai Healthy Volunteers
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Abstract
The objectives of this study were to determine the prevalence of sodium lauryl sulfate (SLS) allergy in Thai healthy volunteers and investigate the association between SLS allergy and self-reported recurrent aphthous stomatitis (RAS) history. This study collected data from 71 Thai healthy participants at the Faculty of Dentistry, Prince of Songkla University. Eligible participants received 0.5% SLS and distilled water (negative control) patch testing on the forearm for 48 hours. Twenty-four hours after removal of the patch testing, participants were recalled for a test interpretation. In addition, participants were also requested to respond to the baseline characteristics and related history of RAS, including the presence of RAS and the number, size, duration, frequency, location, prodromal symptoms, family history, and stress related to RAS. Descriptive statistics described baseline characteristics, characteristics of RAS, SLS allergy interpretation, and prevalence of SLS allergy among Thai healthy subjects. Fisher’s exact test was used to determine the association between SLS allergy and RAS history. The results showed that the prevalence of SLS allergy was 81.82% in Thai healthy subjects. The subjects with a history of RAS were mainly female, usually presenting one RAS ulcer with ≤ 5 mm size of ulcer located on non-keratinized mucosa, of less than one week in duration, occurring over three times per year, presenting prodromal symptoms, and being related to family history. All subjects with a history of RAS were 100% positive for SLS allergy; in contrast, subjects without a history of RAS were 67.74% positive for SLS. A significant association was found between SLS allergy and self-reported RAS history (p=0.003). However, no significant association between the scoring level of SLS allergic reactions and self-reported RAS history was found. In conclusion, SLS allergy is associated with self-reported RAS events. Therefore, SLS allergy should be considered as one factor in patients with a history of RAS.
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บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการลงตีพิมพ์ในวิทยาสารทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่นถือเป็นลิขสิทธิ์เฉพาะของคณะทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่น หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใด ๆ จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษร จากคณะทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่นก่อนเท่านั้น
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