Comparison of Bone Level, Height and Volume in Alveolar Bone Grafting with and without Platelet-rich Fibrin: A Systematic Review and Meta-Analysis

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Jakkapong Kitsomjet
Pattaramon Rattanapan
Porjai Pattanittum
Siwanon Rattanakanokchai
Angkana Klangthong

Abstract

There are many factors that affect failure of alveolar bone grafting with iliac crest bone graft. Some studies showed that platelet rich fibrin (PRF) can increase success rate of surgery but there was no definite result in success rate of alveolar bone grafting with iliac crest bone graft with platelet rich fibrin use. This systematic review and meta-analysis compares effect of platelet rich fibrin use in alveolar bone height, level and volume of bone grafting. There were 1,713 studies from PubMed, Cochrane Controlled Register of Trials (CENTRAL), Science Direct, Google scholar, Clinical Trials. gov, Grey literature and hand searching. Five studies were included to this study which have 1.00 of Kappa coefficient between two reviewers. There was only one from five studies which was rated in high risk by Cochrane risk of bias assessment. Three of five studies were included in meta-analysis. I2 showed 71% of heterogeneity, so the random effect model was used to analyse the overall effect.  This study founded that mean difference of bone volume percentage were increased 7.42% (p=0.14) in alveolar bone grafting with iliac crest bone graft with platelet rich fibrin group at 95% confidence interval of -2.32 -17.22. The overall effect size of this study which showed favourable tendency on PRF group with no statistical difference, suggests need for further studies with larger sample size to strongly support the benefit of platelet rich fibrin use in alveolar cleft bone grafting with iliac crest bone graft.

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1.
Kitsomjet J, Rattanapan P, Pattanittum P, Rattanakanokchai S, Klangthong A. Comparison of Bone Level, Height and Volume in Alveolar Bone Grafting with and without Platelet-rich Fibrin: A Systematic Review and Meta-Analysis. Khon Kaen Dent J [Internet]. 2022 Mar. 16 [cited 2022 Dec. 5];25(1):14-22. Available from: https://he01.tci-thaijo.org/index.php/KDJ/article/view/243458
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