The Retrospective Study of Prevalence, Treatment and Recurrence Rate of Odontogenic Keratocyst (OKC) in Faculty of Dentistry, Khon Kaen University

Main Article Content

Anutida Tiranon
Waranya Kongyadee
Poramaporn Klanrit
Pattaramon Rattanapan

Abstract

The purpose of this retrospective, descriptive study was to study the prevalence, distribution, treatment modalities and recurrence rate of odontogenic keratocyst (OKC) cases from 2008 to 2019 in Faculty of Dentistry, Khon Kaen University. Prevalence and distribution of OKC were analyzed from the patients who were diagnosed histologically as OKC during 2008 to 2019 from database of the Oral Pathology Unit, Faculty of Dentistry, Khon Kaen University. The treatment modalities and recurrence rate were analyzed from treatment records of the OKC patients who were treated in Faculty of Dentistry, Khon Kaen University. The Results from 187 cysts in 169 patients showed the prevalence of OKC was 15.4 % of all odontogenic cyst. OKCs occurred predominantly in female (54.4%) and in the second decades of life (36%). The most common site were the posterior region of mandible (49.7%). Most of the lesions were unilocular radiolucency (66.1%). Of which, 39 patients 59 cysts were treated in Faculty of Dentistry, KKU. Average follow-up period was 53 months. The overall recurrence rate was 12.3%. The recurrence occurred more frequently in OKCs that were multilocular radiolucency (16.7%) and were treated by enucleation followed by carnoy’s solution application. There was no recurrence found in patients treated by resection and enucleation followed by adjunctive measures (other than carnoy’s solution). In addition, as the overall recurrence rate in this study was relatively low, we recommend to choose the conservative treatment as much as possible to achieve the least morbidity. However, resection is recommended in syndromic OKCs patients or multiple recurrent OKC lesions. All recurrences in this study were occurred in the first 5 years after the operation. Therefore, proper treatments and long term follow up for at least 5 years are recommended

Article Details

How to Cite
1.
Tiranon A, Kongyadee W, Klanrit P, Rattanapan P. The Retrospective Study of Prevalence, Treatment and Recurrence Rate of Odontogenic Keratocyst (OKC) in Faculty of Dentistry, Khon Kaen University. Khon Kaen Dent J [Internet]. 2020 Dec. 16 [cited 2024 Dec. 22];23(3):66-7. Available from: https://he01.tci-thaijo.org/index.php/KDJ/article/view/242426
Section
Articles
Share |

References

Singh M, Gupta KC. Surgical treatment of odontogenic keratocyst by enucleation. Contemp Clin Dent 2010; 1(4):263-7.

Kaczmarzyk T, Mojsa I, Stypulkowska J. A systematic review of the recurrence rate for keratocystic odontogenic tumour in relation to treatment modalities. Int J Oral Maxillofac Surg 2012;41(6):756-67

Maurette PE, Jorge J, de Moraes M. Conservative treatment protocol of odontogenic keratocyst: a preliminary study. J Oral Maxillofac Surg 2006; 64(3):379-83.

Barnes L, Eveson JW, Sidransky D, Reichart P, editors. Pathology and genetics of head and neck tumours.9th ed. Lyon: IARC press; 2005.

Madras J, Lapointe H. Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. J of the Canadian Dent Assoc 2008;74(2): 165.

Wright JM, Vered M. Update from the 4th edition of the World Health Organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head and neck pathology 2017;11(1):68-77.

Cottom H, Bshena FI, Speight PM, Craig GT, Jones AV. Histopathological features that predict the recurrence of odontogenic keratocysts. J of Oral Pathol & Med 2012; 41(5)408-14.

Lam KY, Chan AC. Odontogenic keratocysts: a clinicopathological study in Hong Kong Chinese. Laryngoscope 2000;110:1328-32.

Simiyu BN, Butt F, Dimba EA, Wagaiyu EG, Awange DO, Guthua SW, et al. Keratocystic odontogenic tumours of the jaws and associated pathologies: a 10-year clinicopathologic audit in a referral teaching hospital in Kenya. J of Cranio-Maxillofac Surg 2013; 41(3):230-4.

Li TJ. The odontogenic keratocyst: a cyst, or a cystic neoplasm? J of dent res 2011;90(2):133-42.

Zecha JA, Mendes RA, Lindeboom VB, van der Waal I. Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies–A 35-year single institution experience. Oral oncol 2010;46(10):740-2.

Cunha JF, Gomes CC, de Mesquita RA, Goulart EM, de Castro WH, Gomez RS. Clinicopathologic features associated with recurrence of the odontogenic keratocyst: a cohort retrospective analysis. Oral surg, oral med, oral pathol and oral radiol 2016;121(6):629-35.

Mohammad S, Khan M, Mansoor N. Histopathological Types of odontogenic keratocyst: a study. Pakistan Oral & Dent J 2017;37(2):242-4.

Zhao Y, Liu B, Han Q, Wang Y, Wang S. Changes in bone density and cyst volume after marsupialization of mandibular odontogenic keratocysts (keratocystic odontogenic tumors). J of Oral and Maxillofac Surg 2011;69(5):1361-66.

Zhao YF, Wei JX, Wang SP. Treatment of odontogenic keratocysts: a follow-up of 255 Chinese patients. Oral Surg, Oral Med, Oral Pathol, Oral Radiol, and Endod 2002;94(2):151-6.

Nakamura N, Mitsuyasu T, Mitsuyasu Y, Taketomi T, Higuchi Y, Ohishi M. Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol and Endod 2002;94(5):543-53.

August M, Faquin WC, Troulis MJ, Kaban LB. Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression. J of oral and maxillofac surg 2003;61(6):678-83.

Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral surg Oral med Oral pathol Oral radiol and Endod 2006;101(1):5-9.

Berge TI, Helland SB, Sælen A, Øren M, Johannessen AC, et al. Pattern of recurrence of nonsyndromic keratocystic odontogenic tumors. Oral surg Oral med Oral pathol and Oral radiol 2016; 122(1):10-6.

Pitak-Arnnop P, Chaine A, Oprean N, Dhanuthai K, Bertrand JC, Bertolus C. Management of odontogenic keratocysts of the jaws: a ten-year experience with 120 consecutive lesions. J of Cranio-Maxillofac Surg 2010; 38(5):358-64.

Stoelinga PJ. The treatment of odontogenic keratocysts by excision of the overlying, attached mucosa, enucleation, and treatment of the bony defect with Carnoy solution. J of oral and maxillofac surg 2005; 63(11):1662-6.

Tolstunov L, Treasure T. Surgical treatment algorithm for odontogenic keratocyst: combined treatment of odontogenic keratocyst and mandibular defect with marsupialization, enucleation, iliac crest bone graft, and dental implants. J of oral and maxillofac surg 2008; 66(5): 1025-36.

Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol and Endod 2000;90(5):553-8.

Raucharernporn S, Kriangcherdsak Y, Chaiyasamut T, Prachyamuneewong J, Wongsirichat N. A 10-year study on the incidence of oral maxillofacial lesions in the department of Oral Maxillofacial Surgery, Mahidol University: Keratocystic Odontogenic Tumor. M Dent J 2015;35:137-46.

Chow HT. Odontogenic keratocyst: a clinical experience in Singapore. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:573-77.

Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, Lee JH, Choi JY, Seo BM, Kim MJ. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol and Endod 2001;91(3):328-33.

Stoelinga PJ. Long-term follow-up on keratocysts treated according to a defined protocol. Int J of oral and maxillofac surg 2001;30(1):14-25.

Morgan TA, Burton CC, Qian F. A retrospective review of treatment of the odontogenic keratocyst. J of oral and maxillofac surg 2005;63(5):635-9.

Brannon RB. The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surg Oral Med Oral Pathol 1976;42:54-72.

Crowley TE, Kaugars GE, Gunsolley JC. Odontogenic keratocysts: a clinical and histologic comparison of the parakeratin and orthokeratin variants. J Oral Maxillofac Surg 1992;50:22-6.

Partridge M, Towers JF. The primordial cyst (odontogenic keratocyst): its tumour-like characteristics and behaviour. British J of Oral and Maxillofac Surg 1987;25(4):271-9.

Madras J, Lapointe H: Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. J Can Dent Assoc 2008;74(2):165.

Al-Moraissi EA, Dahan AA, Alwadeai MS, Oginni FO, Al-Jamali JM, Alkhutari AS, et al. What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor?: A large systematic review and meta-analysis. J of Cranio-Maxillofac Surg 2017;45(1):131-44.

Ecker J, Horst RT, Koslovsky D. Current role of carnoy's solution in treating keratocystic odontogenic tumors. Journal of oral and maxillofacial surgery: official J of the American Assoc of Oral and Maxillofac Surg 2016; 74(2):278-82.

Belenguer AD, Torres AS, Gay-Escoda C. Role of carnoy's solution in the treatment of keratocystic odontogenic tumor: A systematic review. Medicina Oral Patologia Oral y Cirugia Bucal 2016;21(6)689-95.

Tabrizi R, Omidi M, Dehbozorgi M, Hekmat M. Correlation of radiographic features and treatments with the frequency of recurrence in odontogenic keratocysts of the mandible. J of Craniofac Surg 2014;25(5):e413-7.

Berge TI, Helland SB, Sælen A, Øren M, Johannessen AC, Skartveit L, et al. Pattern of recurrence of nonsyndromic keratocystic odontogenic tumors. Oral surg oral med oral pathol and oral radiol 2016;122(1): 10-6.