Pharmacology in Endodontics
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Published:
Dec 28, 2019
Keywords:
Antibiotics Analgesics Anxiolytics Systemic disease
Main Article Content
Abstract
The root canal infection from dental caries or trauma without any treatment might create apical periodontitis and diffused infection. In this case, antibiotics are needed for prevention and infection controlled. Nowadays, drug-resistance bacteria are one of the problems as prescribe one antibiotic might affect the etiology of bacteria in a whole body. Therefore, the indication of prescribe each antibiotic must be considered. Furthermore, dental pain is also the chief complaint that patients came to see dentist. Analgesics and anxiolytics drugs are helpful to treat pain and any anxiety for patients. For under systemic diseases patients, the chronic symptom and many drugs taken might affect the health and present illness of the patients, that is necessary for the dentist to evaluate and getting proper treatment plan. This article reviews the principle of antibiotics, analgesics and anti-anxiety usage, the side effect and dose of each drug, and also the management of patient with systemic disease before endodontic treatment.
Article Details
How to Cite
1.
Saibua B, Jainaen A. Pharmacology in Endodontics. Khon Kaen Dent J [Internet]. 2019 Dec. 28 [cited 2024 Dec. 22];22(2):172-86. Available from: https://he01.tci-thaijo.org/index.php/KDJ/article/view/159226
Issue
Section
Review Article
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการลงตีพิมพ์ในวิทยาสารทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่นถือเป็นลิขสิทธิ์เฉพาะของคณะทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่น หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใด ๆ จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษร จากคณะทันตแพทยศาสตร์ มหาวิทยาลัยขอนแก่นก่อนเท่านั้น
References
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12. Hersh EV, Moore PA. Drug interactions in dentistry: the importance of knowing your CYPs. J Am Dent Assoc 2004;135(3):298-311.
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20. Kim ST, Abbott PV, McGinley P. The effects of Ledermix paste on discolouration of immature teeth. Int Endod J 2000; 33(3):233–7.
21. Andersson L, Andreasen JO, Day P, Heithersay G, Trope M, Diangelis AJ, et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol 2012;28(2):88-96.
22. Tolentino Ede S, Centurion BS, Ferreira LH, Souza AP, Damante JH, Rubira-Bullen IR. Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients. J Appl Oral Sci 2011;19(5):448-54.
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26. Raaj SS, Ramulu S, Neelakantan P .Pharmacotherapy in Root Canal Treatment. Res J Pharm Biol Chem Sci 2014;5(3): 43-50.
27. Hargreaves KM. A “3D” Approach for Treating Acute Pain [homepage on the Internet]. ENDODONTICS: Colleagues for Excellence newsletter. Winter 2015. Available from: https:// www.aae.org/specialty/wp-content/uploads/sites/2/ 2017/07/ecfeacutedentalpain.pdf
28. Hersh EV, Moore PA.Three Serious Drug Interactions that Every Dentist Should Know About. Compend Contin Educ Dent 2015;36(6):408-13.
29. Khan IH. Lithium and non-steroidal anti-inflammatory drugs. BMJ 1991;302(6791):1537-8.
30. Seymour RA. Drug interactions in dentistry. Dent Update 2009;36(8):458-60, 463-6, 469-70.
31. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2015;352 (11),1092-102.
32. Hargreaves KM, Abbott PV. Drug for pain management in dentistry. Aust Dent J 2005;50(4):14-22.
33. Kerckhove N, Mallet C, Francois A, Boudes M, Chemin J, Voets T, et al. Ca(v)3.2 calcium channels: the key protagonist in the supraspinal effect of paracetamol. Pain 2014;155(4):764-72.
34. U.S. Food and Drug Administration [homepage on the Internet]. FDA Drug Safety Communication: Prescription Acetaminophen Products to be Limited to 325 mg Per Dosage Unit; Boxed Warning Will Highlight Potential for Severe Liver Failure [updated 2018 Jul 02]. Available from:https://www.fda.gov/drugs/drugsafety/ucm239821.htm
35. Hargreaves KM, Troullos ES, Dionne RA. Pharmacologic rationale for the treatment of acute pain. Dent Clin North Am 1987;31(4):675-94.
36. Mehlisch DR, Aspley S, Daniels SE, Southerden KA, Christensen KS. A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study. Clin Ther 2010;32(6):1033-49.
37. Keiser K, Hargreaves KM. Building effective strategies for the management of endodontic pain. Endod Topics 2002;3(1):93–105.
38. Reader A, Nusstein J, Khan A. Cohen’s Pathways of the Pulp Expert Consult 11th Edition 2015:121-2.
39. Silva NM, Anjos Neto. Systemic medication applied to endodontic treatment: a literature review. RSBO 2014;11 (3):293-302.
40. Scully C, Ettinger RL. The influence of systemic diseases on oral health care in older adults. J Am Dent Assoc 2007; 138:7-14.
41. Scully C. Scully’s Medical Problems in Dentistry. 7th ed. London: Churchill Livingstone;2014.125-334.
42. Sloss A, Kubier P. Prescribing in liver disease. Aust Prescr 2009;32:32-5.
43. Cengiz SB. The pregnant patient: Considerations for dental management and drug use. Quintessence Int 2007;38 (3):133-42.
2. Craig J. Antibiotics and the Treatment of Endodontic Infections [homepage on the Internet]. ENDODONTICS: Colleagues for Excellence newsletter. Summer 2006. Available from: https://www.aae.org/specialty/wp-content/uploads/ sites/2/2017/07/summer06ecfe.pdf
3. Abbott PV, Hume WR, Pearman JW. Antibiotics and Endodontics. Aust Dent J 1990;35(1):50-60.
4. Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med 2015;372(16):1539-48.
5. Segura-Egea JJ, Gould K, Şen BH, Jonasson, P, Cotti E, Mazzoni A, Sunay H, Tjäderhane L, Dummer PMH. European Society of Endodontology position statement: the use of antibiotics in endodontics. Int Endod J 2018;51(1):20-5.
6. Hinckfuss SE, Messer LB. An evidence-based assessment of the clinical guidelines for replanted avulsed teeth. Part II: prescription of systemic antibiotics. Dent Traumatol 2009;25(2):158-64.
7. Diangelis AJ, Andreasen JO, Ebeleseder KA, Kenny DJ, Trope M, Sigurdsson A, et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 1. Fractures and luxations of permanent teeth. Dent Traumatol 2012;28(1):2-12.
8. AAE Position Statement: AAE Guidance on the Use of Systemic Antibiotics in Endodontics. J Endod 2017 Sep;43(9):1409-13.
9. Wright AJ. The penicillins. Mayo Clin Proc 1997;74(3): 290-307.
10. Nikaido H. Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin Infect Dis 1998;27(1):32–41.
11. Reusser F. Effect of lincomycin and clindamycin on peptide chain initiation. Antimicrob Agents Chemother 1975;7 (1):32-7.
12. Hersh EV, Moore PA. Drug interactions in dentistry: the importance of knowing your CYPs. J Am Dent Assoc 2004;135(3):298-311.
13. Hersh EV. Adverse drug interactions in dental practice: interactions involving antibiotics. Part II of a series. J Am Dent Assoc 1999;130(2):236-51.
14. Hersh EV, Moore PA. Adverse drug interactions in dentistry. Periodontol 2000 2008;46:109-42.
15. International Association of Dental Traumatology. Dental Trauma Guidelines Revised 2012 [homepage on the Internet]. Available from:https://www.iadt-dentaltrauma. org/1-9%20%20iadt%20guidelines%20combined%20 -%20lr%20-%2011-5-2013.pdf
16. Diogenes A, Henry MA, Teixeira FB, Hargreaves KM. An update on clinical regenerative endodontics. Endod Topics 2013;28(1):2–23.
17. AAE Clinical Considerations for a Regenerative Procedure [homepage on the Internet]. Available from: https://www. aae.org/specialty/wp-content/uploads/sites/2/2018/06/ ConsiderationsForRegEndo_AsOfApril2018.pdf
18. Chance, K, Lin, L, Shovlin, FE, Skribner, J. Clinical trial of intracanal corticosteroid in root canal therapy. J Endod 1987;13(9):466-8.
19. Pierce An, Heithersay G, Lindskog S. Evidence for direct inhibition of dentinoclasts by a corticosteroid/antibiotic endodontic paste. Endod Dent Traumatol 1988;4(1):44-5.
20. Kim ST, Abbott PV, McGinley P. The effects of Ledermix paste on discolouration of immature teeth. Int Endod J 2000; 33(3):233–7.
21. Andersson L, Andreasen JO, Day P, Heithersay G, Trope M, Diangelis AJ, et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol 2012;28(2):88-96.
22. Tolentino Ede S, Centurion BS, Ferreira LH, Souza AP, Damante JH, Rubira-Bullen IR. Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients. J Appl Oral Sci 2011;19(5):448-54.
23. Dannemann C, Gratz KW, Riener MO, Zwahlen RA. Jaw osteonecrosis related to bisphosphonate therapy: a severe secondary disorder. Bone 2007;40(4):828-34.
24. Fouad AF, Chair, Byrne BE, Diogenes AR, Sedgley CM, Cha BY. AAE Guidance on Antibiotic Prophylaxis for Patient at Risk of Systemic Disease [homepage on the Internet]. Available from: https://www.aae.org/specialty/wp-content/uploads/ sites/2/2017/06/aae_antibiotic-prophylaxis.pdf
25. Sollecito TP, Abt E, Lockhart PB, Truelove E, Paumier TM, Tracy SL, et al. The use of prophylactic antibiotics prior to dental procedures in patients with prosthetic joints: Evidence-based clinical practice guideline for dental practitioners--a report of the American Dental Association Council on Scientific Affairs. J Am Dent Assoc 2015; 146(1):11-6.
26. Raaj SS, Ramulu S, Neelakantan P .Pharmacotherapy in Root Canal Treatment. Res J Pharm Biol Chem Sci 2014;5(3): 43-50.
27. Hargreaves KM. A “3D” Approach for Treating Acute Pain [homepage on the Internet]. ENDODONTICS: Colleagues for Excellence newsletter. Winter 2015. Available from: https:// www.aae.org/specialty/wp-content/uploads/sites/2/ 2017/07/ecfeacutedentalpain.pdf
28. Hersh EV, Moore PA.Three Serious Drug Interactions that Every Dentist Should Know About. Compend Contin Educ Dent 2015;36(6):408-13.
29. Khan IH. Lithium and non-steroidal anti-inflammatory drugs. BMJ 1991;302(6791):1537-8.
30. Seymour RA. Drug interactions in dentistry. Dent Update 2009;36(8):458-60, 463-6, 469-70.
31. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2015;352 (11),1092-102.
32. Hargreaves KM, Abbott PV. Drug for pain management in dentistry. Aust Dent J 2005;50(4):14-22.
33. Kerckhove N, Mallet C, Francois A, Boudes M, Chemin J, Voets T, et al. Ca(v)3.2 calcium channels: the key protagonist in the supraspinal effect of paracetamol. Pain 2014;155(4):764-72.
34. U.S. Food and Drug Administration [homepage on the Internet]. FDA Drug Safety Communication: Prescription Acetaminophen Products to be Limited to 325 mg Per Dosage Unit; Boxed Warning Will Highlight Potential for Severe Liver Failure [updated 2018 Jul 02]. Available from:https://www.fda.gov/drugs/drugsafety/ucm239821.htm
35. Hargreaves KM, Troullos ES, Dionne RA. Pharmacologic rationale for the treatment of acute pain. Dent Clin North Am 1987;31(4):675-94.
36. Mehlisch DR, Aspley S, Daniels SE, Southerden KA, Christensen KS. A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study. Clin Ther 2010;32(6):1033-49.
37. Keiser K, Hargreaves KM. Building effective strategies for the management of endodontic pain. Endod Topics 2002;3(1):93–105.
38. Reader A, Nusstein J, Khan A. Cohen’s Pathways of the Pulp Expert Consult 11th Edition 2015:121-2.
39. Silva NM, Anjos Neto. Systemic medication applied to endodontic treatment: a literature review. RSBO 2014;11 (3):293-302.
40. Scully C, Ettinger RL. The influence of systemic diseases on oral health care in older adults. J Am Dent Assoc 2007; 138:7-14.
41. Scully C. Scully’s Medical Problems in Dentistry. 7th ed. London: Churchill Livingstone;2014.125-334.
42. Sloss A, Kubier P. Prescribing in liver disease. Aust Prescr 2009;32:32-5.
43. Cengiz SB. The pregnant patient: Considerations for dental management and drug use. Quintessence Int 2007;38 (3):133-42.