Adverse Drug Eruption of Topical Plai Cream: A case study

Abstract

          The purpose of this study was to find out the association between adverse drug eruption andtopical Plai Cream. Topical Plai Cream is herbal medicine from 14% of extracted Zingiber cassumunar Roxb and showed in Thai National List of Essential Medicines. Plai Cream has benefits in pain reduction for muscle pain and joint sprain. Some studies of Plai showed about adverse drug reaction but not seriously symptom. This study was a qualitative study as a case report. The employed tool was a Naranjo’s algorithm test comprising 10 items for drug allergy assessment, and the patient data was recorded with deep interview in case record form.
          A 57-year-old female patient presented with complaint of itching and maculopapular rashes involving both anterior things and left latoral back. All affected areas were associated with topical application of Plai Cream in the second time, moreover skin rashes were slightly decreased after stop using. The patient was determined as prohable to Plai Cream allergy (total score = 5, Naranjo's algorithm). Treatments consisted of intravenous histamine and topical steroid cream. Disappearance of all skin rashes was observed at a period
of 16 days later.