COVID Vaccination in Pregnant Women : An Umbrella Review

Abstract

An Umbrella review of systematic reviews and meta-analyses. This study aims to synthesize existing evidence on the effects of COVID vaccination in pregnant women. The research follows the Joanna Briggs Institute (JBI) framework and includes studies published between 2020 to 2024. The research tools comprised: 1) Inclusion criteria form 2) Critical appraisal form and 3) Data extraction form. Analyze the data by narrative summary
An Umbrella review of systematic reviews and meta-analyses included 26 studies. Results demonstrated that COVID vaccination in pregnant women effectively prevents COVID infection, reduces disease severity, and found that maternal vaccination during pregnancy was reduce to length of hospital stay, miscarriage, preterm birth, intrauterine growth restriction, low birth weight, abruptio placenta, amniotic sac infection, stillbirth, low Apgar score at 5 min (<7) and postpartum hemorrhage, and has no effect on increasing the risk of developing pregnancy induce hypertension, cesarean section, vacuum extraction, admission to the intensive care unit. Adverse effects of vaccination in pregnant women were not significantly different from those observed in unvaccinated pregnant women. However, there are some studies that cannot be conclusively conclusive about the effect on pregnant women, which are less common, such as miscarriage, premature birth, postpartum hemorrhage, and thrombocytopenia or coagulopathy. The findings from this An Umbrella review of systematic reviews and meta-analyses should guide clinical practices for prenatal care to mitigate potential adverse outcomes for both pregnant women and their infants. COVID vaccination is strongly supported as a safe and effective intervention during pregnancy.