The Effectiveness of 3 Months Regimen of Isoniazid Plus Rifampicin for Treatment of Latent Tuberculosis Infection in Children
Keywords:latent tuberculosis infection, 3HR, feasibility, adherence, tolerability
The purpose of this retrospective study was to determine the feasibility, adherence, and tolerability of 3HR treatment in children exposed to tuberculosis during hospitalization. Conducted over 2-year period in Siriraj hospital from February 2020 to February 2022. The adherence and the adverse drug reactions were collected by self report during follow-up. As well, the rate of active TB disease was evaluated.
Results : There were 267 exposed children and 182 (68.2%) received 3HR, median age was 1.4 years (IQR 0.46-3.51). Overall adherence was good and 97.7% completed the treatment.Serious drug-related adverse events were not found. Adverse events were reported in 8 (4.4%) patients: vomiting (5 (2.8%)) and transaminitis (3 (1.6%)). There were 4 (2.2%) patients discontinued treatment due to adverse events.2 (0.75%) cases of all exposed children had developed TB disease over 12 months follow-up, none were those who completed the treatment. Conclusions: Tuberculosis preventive treatment with 3HR is feasible, well tolerability, with high adherence rate, and effective in preventing TB disease. Therefore, health educators and nurses who play a role in caring for patients must understand the pathophysiology and common complications. To lead to nursing and teaching health education to guide children with heart disease and their families effectively. Principles of caring for this group of sick children should focus on teaching and giving advice to caregivers in caring for children with heart disease. congenital efficiency Nurses also play an important role in keeping children with heart disease safe and sound.out of the crisis of the disease and have a good quality of life
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