Weight change and associated factors in children and adolescents with depression after 1 year treatment at Siriraj hospital
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Abstract
Objectives: This study aimed to investigate weight changes in children and adolescents with depressive disorder after 1 year of treatment, and to explore the associations between weight gain and associated factors.
Methods: A retrospective chart review was conducted on children and adolescents diagnosed with depressive disorder by psychiatrist at Siriraj Hospital from 2013 to 2019. Initial and post-1-year treatment weights were collected and categorized into 5 groups (very underweight, underweight, average, overweight, and obese) based on standard growth curves. Associated factors, including gender, age, type and duration of medication, comorbidities, and substance use, were recoded. Data were analyzed using mean, median, mode, and logistic regression analyses.
Results: This study included 202 cases, with an average age of 13.8 years. After 1 year of treatment, 141 cases (69.7%) showed no changes in weight, 18 cases (9.0 %) exhibited weight loss, and 43 cases (21.3 %) demonstrated weight gain. Logistic regression analyses revealed that the initial weight groups of very underweight (OR=6.78 (1.25–36.37), p=0.026), underweight (OR=10.61 (3.59–31.34), p<0.001), and overweight (OR=10.97 (3.93–30.58), p<0.001) were significantly associated with weight gain compared to the average weight group. Other studied factors were not associated with weight gain after 1 year of treatment.
Conclusions: The majority of children and adolescents with depressive disorder do not experience weight changes after 1 year of treatment. Factors associated with weight change include the initial weight, with the very underweight, underweight and overweight groups showing significant associations with weight gain.
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