Health-Related Quality of Life of Outpatients with Depression Treated with Antidepressants at King Chulalongkorn Memorial Hospital

Main Article Content

Jirada Prasartpornsirichoke
Nuttorn Pityaratstian
Naphat Sirinimnualkul
Chayanit Poolvoralaks
Tanaporn Ormtavesub
Sasitorn Phonsit
Nimmavadee Hiranwattana
Teerayuth Rungnirundorn


Objective: To explore health-related quality of life (HRQoL) among outpatients with depression treated with antidepressants who visited King Chulalongkorn Memorial Hospital during March-July 2022 and to investigate the difference in health-related quality of life between patients with treatment-resistant depression and patients with treatment-response depression.

Methods: This descriptive study included a cross-sectional survey of 500 depressed patients using the Thai-language short-form 36 health-related quality of life questionnaire and a retrospective review of patient medical records to evaluate if patients responded to depression treatment. The distinction between the two categories of depressed patient's quality of life was examined using an independent T-test.

Results: The health-related quality of life of treatment-resistant depressive patients was significantly worse than that of treatment-response depressive patients in dimensions of role limitations due to physical health (mean difference = -13.581, P<0.001, Cohen’s d = -0.380), general health (mean difference = -7.070, P = 0.003, Cohen’s d = -0.332), role limitations due to emotional problems (mean difference = -14.358, P<0.001, Cohen’s d = -0.432), vitality (mean difference = -13.479, P<0.001, Cohen’s d = -0.858), social functioning (mean difference = -20.514, P<0.001, Cohen’s d = -0.801), and mental health (mean difference = -13.855, P < 0.001, Cohen’s d = -0.907).

Conclusion: This study confirmed that the health-related quality of life of treatment-resistant depressive patients was statistically significantly worse than that of treatment-response depressed patients in almost every aspect. Understanding treatment-resistant depression can have a positive impact on long-term quality of life for depressed patients.

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How to Cite
Prasartpornsirichoke, J., Pityaratstian, N., Sirinimnualkul, N., Poolvoralaks, C. ., Ormtavesub, T., Phonsit, S., Hiranwattana, N. ., & Rungnirundorn, T. (2023). Health-Related Quality of Life of Outpatients with Depression Treated with Antidepressants at King Chulalongkorn Memorial Hospital. Journal of the Psychiatric Association of Thailand, 68(3), 254–264. Retrieved from
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