Prospective Cohort Study of 1-Year Incidence of Cognitive Impairment in Patients with Elderly Depression at Psychiatric Outpatient Unit, Ramathibodi Hospital
Objective : To study incidence of cognitive impairment among elderly patients with depression
during one year and the factors that associated with cognitive impairment of elderly patients
Method : This prospective cohort study was conducted in 87 elderly patients with depression.
The research instrument includes demographic and depression data, Hamilton Rating Scale
for Depression (HAMD-17), Mini-Cognitive Assessment Instrument (Mini-Cog), AD-8 and
Montreal Cognitive Assessment (MoCA) or Montreal Cognitive Assessment-Basic (MoCA-B).
Data were then analyzed in term of descriptive statistics, chi-square test and independent
Results : Incidence of dementia among elderly patients with depression during one year was
24.1%. Factors associated with dementia included age, family history of psychiatric illness,
age at onset of depression, duration of treatment and the problems in 6 cognitive function
domains. MoCA scores between patients with and without dementia were statistically different;
however, severity of depression assessed with HAMD-17 and AD-8 scores were not statistically
Conclusion : Elderly patients with depression are at risk of dementia and problems with
cognitive function. Continually screening, surveillance and prevention of dementia should be
conducted among elderly patients with depression.