Prospective Cohort Study of 1-Year Incidence of Cognitive Impairment in Patients with Elderly Depression at Psychiatric Outpatient Unit, Ramathibodi Hospital

Main Article Content

Chatchaya Pienjongkol
Papan Thaipisuttikul


Objective : To study incidence of cognitive impairment among elderly patients with depression
during one year and the factors that associated with cognitive impairment of elderly patients
with depression
Method : This prospective cohort study was conducted in 87 elderly patients with depression.
The research instrument includes demographic and depression data, Hamilton Rating Scale
for Depression (HAMD-17), Mini-Cognitive Assessment Instrument (Mini-Cog), AD-8 and
Montreal Cognitive Assessment (MoCA) or Montreal Cognitive Assessment-Basic (MoCA-B).
Data were then analyzed in term of descriptive statistics, chi-square test and independent
Results : Incidence of dementia among elderly patients with depression during one year was
24.1%. Factors associated with dementia included age, family history of psychiatric illness,
age at onset of depression, duration of treatment and the problems in 6 cognitive function
domains. MoCA scores between patients with and without dementia were statistically different;
however, severity of depression assessed with HAMD-17 and AD-8 scores were not statistically
Conclusion : Elderly patients with depression are at risk of dementia and problems with
cognitive function. Continually screening, surveillance and prevention of dementia should be
conducted among elderly patients with depression.

Article Details

How to Cite
Pienjongkol, C. ., & Thaipisuttikul, P. . (2020). Prospective Cohort Study of 1-Year Incidence of Cognitive Impairment in Patients with Elderly Depression at Psychiatric Outpatient Unit, Ramathibodi Hospital. Journal of the Psychiatric Association of Thailand, 65(1), 89–102. Retrieved from
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