Cases Report: Intravenous Ketamine Infusion for Treatment-Resistant Depression
Objective : To report the results of intravenous ketamine infusion in treatment resistant
Method : We report 2 patients (treatment resistant bipolar disorder, currently major
depressive episode, and major depressive disorder) who received ketamine infusion
treatment. The clinical data, ketamine infusion process, benefits and adverse effects
were described. Previous studies on ketamine mechanism and therapeutic use was
Results : The depressive symptoms of both cases improved. Both patients reached
the criteria for treatment response within 1 week then remitted clinically within 3-4 weeks.
Significant decreasing of suicidal ideation was also reported. No remarkable adverse
effects from ketamine infusion occurred.
Conclusion : Intravenous ketamine infusion therapy for treatment resistant major
depressive episode was beneficial and safe in these 2 cases. Further researches
regarding its efficacy and safety should be conducted to support the efficacy and
safety of this novel treatment method in Thailand.
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