Abnormal Thyroid Function in Patients with Mood Disorders: Prevalence and Associated Factors
Introduction : Mood disorders have high life-time prevalence and cause significant disabilities.
Hypothalamic-pituitary-thyroid (HPT) axis dysfunction has been reported in patients with mood
disorders, but the prevalence and its associations have yet to be established.
Objectives : To study the prevalence of abnormal thyroid function and associated factors in
patients with mood disorders
Material and Methods : In this retrospective descriptive study,medical records of patients with
mood disorders, including Major Depressive Disorder, Persistent Depressive Disorder
(Dysthymia), BipolarI Disorder, Bipolar II Disorders and Cyclothymia, from January 1st, 2011
to August 31st,2016 were reviewed. Collected data included demographic data, underlying
medical conditions, psychiatric diagnoses, medications, history of electroconvulsive therapy,
and results of thyroid function test (TFT). Statistical analyses were performed using STATA
Results : From a total of 252 medical records,144 (57.14%) patients had complete data on
TFT, and 49 (34.03%) patients had abnormal TFT;40 patients had abnormal FT3; 13 patients
had abnormal TSH; and 2 patients had abnormal FT4. Factors including female gender and
the use of second generation antipsychotics showed statistically significant association with
abnormal TFT [adjusted OR 6.17 (95%CI2.5 - 15.23), p<0.001 and adjusted OR 2.3 (95%CI
1.06 - 5.02), p=0.036,respectively]
Conclusion : About one-third of patients with mood disorders had abnormal TFT, and female
gender and the use of second generation antipsychotics were associated with abnormal TFT.
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