Efficacy of lidocaine spray for pain relief during endometrial sampling: A double blind randomized controlled trial
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Abstract
This research aims to study the effectiveness of a 10% lidocaine spray for pain reduction during endometrial sampling using a Wallach Endocell. This randomized controlled trial was conducted at the gynecology outpatient department of Phrae Hospital from October 2023 to February 2024. The sample group consisted of 64 women with an indication for endometrial sampling. Participants were divided into two groups: the experimental group, which received a 10% lidocaine spray (40 mg, 4 sprays) to the cervical surface before the procedure, and the control group, which received a 0.9% saline spray. Pain was assessed using a 10 cm Visual Analogue Scale. Data collection tools included three parts: Part 1 for personal patient information, Part 2 for pain levels, and Part 3 for observing adverse drug reactions and monitoring for severe allergic reactions. The study found no significant differences in the general characteristics of the two groups. However, pain scores were significantly lower (p < 0.05) in the group that received the 10% lidocaine spray compared to the control group. Specifically, pain scores were 3.0 ± 1.3 and 3.8 ± 1.6, respectively, after tenaculum placement, and 3.0 ± 1.3 and 5.3 ± 1.9, respectively, during the tissue sampling, both of which were statistically significant (p < 0.05). Pain scores also remained significantly lower 15 minutes after the procedure. However, at 30 minutes post-procedure, there was no statistically significant difference in pain scores between the lidocaine group (0.22 ± 0.5) and the control group (0.5 ± 0.8) at the 0.05 level.
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References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021;71(3):209-49.
National Cancer Institute, Ministry of Public Health. Cancer Report Form [Internet]. Bangkok: National Cancer Institute; 2021 [cited 2023 Jun 6]. Available from: https://www.nci.go.th/e_book/hosbased_2564/index.html
Mahajan N, Aggarwal M, Bagga A. Health issues of menopausal women in North India. Journal of mid-life Health. 2012;3(2):84-7.
Vitale SG, Buzzaccarini G, Riemma G, Pacheco LA, Sardo ADS, Carugno J, et al. Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice. Journal of gynecology obstetrics and human reproduction. 2023;52(6):102588.
Dreisler E, Frandsen CS, Ulrich L. Perimenopausal abnormal uterine bleeding. Maturitas. 2024;183: 107944.
Suwanwanich M. Relative Risk Factors of Abnormal Endometrial Pathologies in Patients with Abnormal Uterine Bleeding. Journal of the Department of Medical Services. 2019;44(5):103-7. (in Thai)
Polena V, Mergui J-L, Zerat L, Sananes S. The role of Pipelle® Mark II sampling in endometrial disease diagnosis. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2007;134(2): 233-7.
Wanijasombutti P, Imruetaicharoenchok A, Tangjitgamol S, Loharamtaweethong K, Phuriputt N, Phaloprakarn C. Comparison of tissue adequacy for histologic examination from Ipas MVA plus and Wallach Endocell in women with abnormal uterine bleeding. Journal of Obstetrics and Gynaecology Research. 2015;41(8):1246-54.
Likkasittipan N, Wiriyasirivaj B. Effect of Lidocaine Gel for Pain Relief during Endometrial Sampling: A double-blinded randomized controlled trial. Thai J Obstet Gynaecol. 2021;29(5):273-80. (in Thai)
Williams PM, Gaddey HL. Endometrial biopsy: Tips and pitfalls. American Family Physician. 2020;101(9):551-6.
Korsuwan P, Wiriyasirivaj B. Lidocaine spray for pain control during office-based endometrial biopsy: A randomized placebo-controlled trial. Thai J Obstet Gynaecol. 2018;26(4):262-9. (in Thai)
Moradan S, Rezaeianzadeh R, Foroumadi M, Moradan N, Zohrehvandi F. Medications for pain relief in outpatient endometrial sampling or biopsy: A systematic review and network meta-analysis. BMC Womens Health. 2022;22(1):86.
Simsek M, Kaya O, Kıratlı M, Simsek H, Yilmaz B. Methods of pain control during endometrial biopsy: A systematic review and meta-analysis of randomized controlled trials. J Minim Invasive Gynecol. 2020;27(1):153-62.
Aksoy H, Aksoy U, Ozyurt S, Acmaz G, Babayigit MA, Yücel B, et al. Effect of lidocaine spray in pain management during office-based endometrial sampling: A randomised placebo-controlled trial. Journal of Obstetrics and Gynaecology. 2016;36(2):246-50.
Luangtangvarodom W, Pongrojpaw D, Chanthasenanont A, Pattaraarchachai J, Bhamarapravatana K, Suwannarurk K. The Efficacy of Lidocaine Spray in Pain Relief during Outpatient‐Based Endometrial Sampling: A Randomized Placebo‐Controlled Trial. Pain Research and Treatment. 2018;2018:1238627.
