Determination of Serum Proteins in Long-term Plasmapheresis Donors

บทคัดย่อ

Abstract :

In a retrospective study data from 314 plasmapheresis donors aged ranging from 22 to 56 years at the
Hemapheresis Unit, the Reference Laboratory, in WHO Co-Operative, the National Blood Centre, Thai Red Cross
Societyfrom January 2000 to December 2004 were analyzed. Individuals weighing more than 50 kg, donated 500 mL
of plasma per session. Total serum protein and albumin were determined at the first donation and every 6 month
throughout a 42-month donation period. Donors were divided into 3 groups according to interval between plasma
donation; two times per month in group 1 (N=13), one time per month in group 2 (N= 113) and one time per two
months in group 3 (N=188). The mean of individual serum protein and albumin remained well within normal ranges
in all donors. There was no significantly different of total serum protein and albumin among these groups. When
the results of serum protein and albumin levels among these three groups at each period were compared with the
resultsp riort ot hef irstd onation,i tw asf oundt hatt heirl evelsw ereg raduallyd ecreased. H owever,w hent heh ighprotein
 diet was suggested the serum protein level was increased (p > 0.05) and only serum albumin level was
significantly increased (p < 0.05), especially in groups 2 and 3, which may be due to high-protein diet. In addition,
serum protein and albumin were analyzed according to donors’ professions and there were no significantly different
in each group (p > 0.05). In conclusion, regular donor plasmapheresis of up to 12 L of plasma per year appears to
besafe with respect to the parameters of total serum protein and albumin analyzed in this study. However,
monitoring of serum proteins as well as dietary and ferrous sulfate supplement is suggested to provide more safety
of long-term donor plasmapheresis.