Paroxysmal Nocturnal Hemoglobinuria in Chiangmai
Keywords:
Anemia, Hemoglobinuria, PNH, DyshemopoiesisAbstract
Abstract: Fifty-one patients with paroysmal noctumal hemoglobinuria (PNH) treated in the Division of Hematology, Department of Medicine, Chiang Mai University, between 1973 and 1997 were reviewed, with emphasis on the comparison with cases from Siriraj Hospital, China, Europe America. Compared with European and American series, the clinical characteristics in our PNH patients included : males were affected more; age of onset was younger; the proportion of cases with previous history of aplastic anemia or dyshemooiesis was more frequent (except for French series); death from thrombosis was rare but from infection was relatively con. Compared to Srira่ Hospital's series, most of the clinical characteristics in our patients were similar excapt for a lower percentage of patients with hemorhagic symptoms and severe thrombocytopenia (platelet count < 50,000/mm3) at presentation.
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