The Effectiveness of Continuous Infusion of Factor VIII Concentrate in Patients with Hemophilia
Keywords:
Continuous infusion, Factor VIII, Hemophilia, InhibitorAbstract
Abstract : A continuous infusion of factor VII centrate was given to 9 patients with hemophilia A (FVIII C < 1% to 3.5%) who received orthopedic surgery (8 cases) or had serious bleeding in vital organs (1 case). The ages ranged from 6 to 18 years old. The patient showed good response with a high and steady level of F VIII C. The continuous infusion of 0.046 unickg/h raised the F VIII:C by 1 U/dL (1%). Thrombophlebitis was found in 4 cases which was minimized by the addition of heparin into the reconstituted factor concentrate. Inhibitor was found in 3 cases. However, no excessive bleeding was found. This study showed that the continuous infusion of factor VII concentrate was effective in controlling bleeding disorders in hemophiliac patients. It is recommended
for hospitalized patient with serious bleeding or undergoing surgery.
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