Normal Cold Agglutinin Titer and Specificity
Keywords:
Cold agglutinin, Anti-I, Anti-i, Anti-HAbstract
Abstract : Normal cold agglutinin (CAl is demonstrable with low titer in the serum of most normal, healthy individuals when testing is done at 4 C. In cases of high titer or wide thermal range, it should be emphasized the clinical significance and sometimes interfere with routine cell and serum tests. The sera of 100 blood donors and 100 patients at Raiavith Hospital were studied for CA titer and
specificity. They were 103 males and 97 females, aged from 11 to 79 years old. Twenty-three of them had no CA. The CA titer 1. 2. 4, 8, 16, 32, 64 and 128 were 41. 41. 31, 39, 18 2, and 1 cases, respectively. The specificity of CA were anti-i anti for 173,2 and 2 cases respectively. Anti-Pr was not found. All of CA in this study were shown to be antibodies of the lgM class. They were inactivated with the dithiothreitol (DTT) IgM - reducing agent.
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