Distribution of Lymphoma Immunophenotypes in Nakhon Si Thammaraj
Keywords:
Lymphoma, Immunophenotyping, PhenotypeAbstract
Abstract : Objective : To study distibution of lymphoma immununobbenotypes in Mahaharai Nakhon Si Thammaraj Hospital which have not been reported before.
Methodes : We analyzed pathological data of Iymphoma at the Pathology Department, Maharai Nakhon Si Thammaraj Hospital for a period of three years (1995-1997). Each cases had been immunophenotypic characterized by using immunoperoxidase technique with basically selected tour monoclonal antibodies, including L-26 for B-cell, UCHL for T-cell, Ki-1 for anaplastic large cell lymphoma, and bcl-2 for follicular carcinoma. The diagnoses based on Revised European-American Classification of Lymphoid Neoplasm.
Results : There were 37 cases of Ivmphoma, 18 of nodal and 19 of extranodal sites. Three cases of Hodgkin's disease were found, all of nodal in origin. Most cases of non-Hodgkin's disease were B-cell phenotype (88.89% nodal and 94.74% extranodal). The age of nodal group ranged from 2 to 83 years old (mean = 51 years) and male.female ratio=1:2, The extranodal group ranged from 21 to 82
years old (mean = 53 years) and male female ratio=1.7:1 Two Ki-1 anaplastic large cell Ivmphomas were included.
Discussion & Conclusion : Our finding of B cell lymphomas predominance in all of the non-Hodgn's lymphomas was comparable to other studies The immunophenotyping of lymphoma provides important informations to categorize the useful diagnoses Thus, the pathologist can classify them in more specific categories and entities which aid the clinician to treat the patients more effectively. At the present time, immunophenotyping of Iymphoma is an essential method that should be used routinely, For economic proposes a minimum set of monoclonal antibodies may be desired with the additional monoclonal antibodies for resolving some troublesome cases.
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