Comparison in Leukocyte Alkaline Phosphatase Activity in Patients with Myeloproliferative Disorders Before and During Disease Transformation

Authors

  • Sriprapa Chinprasertsuk Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,
  • Sanan Visuthisakchai Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,
  • Maneenop Yimyam Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,
  • Wanna Muangsup Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,
  • Tipawan Boonyapanichkul Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,
  • Prayoon Tanomsuk Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,

Keywords:

Leukocyte alkaline phosphatase, Myeloproliferative disorders, Chronic myeloid leukemia, Polycythemia vera, Myelofibrosis, Essential thrombocythemia

Abstract

Abstract : Chronic myeid leukemia (CMI.), polycythemia vera (PV), myelobrosis (MF) and essential thrombocythemia (ET) are chronic myeloproliferative disorders (MPD) with clonal disorder of multipotent hemopoietic stem cells. There is offen considerable overlap between the myeloproliferative disorders and in progression of the diseases, some of them may end up with acute leukemia. Leukocyte alkaline phosphatase (LAP) is helpful in diagnosis and assessment of the stage of MPD. In our studies, LAP score was 49.9+-27.4 in normal control. In CML, CML with myelofibrosis, CML. with blastic transformation and ex CMil after bone marrow transolantation, their LAP score were 0.9+- 2.0, 86+-20.3, 6:3+-191 and 77.8+-67.5 respectively. LAP score in CMI patients increased when the disease transformed and returned to normal level when the patients entered recovery by bone martow transplantation. LAP score in patients with polycythemia vera, myelofibrosis and essential thrombocythemia were 176+-45, 77+-73 and 80+-40 respectively. There were little to marked changes in LAP score when the diseases in this group were transformed. LAP score in a patient with polycythemia vera which had transformed from essential thrombocythemia was as high as LAP score in polycythemia vera patients.

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References

Loszol J. Myeloproliferative disorder (MPD) : myelofibrosis, myelosclerosis, extramedullary hematopoiesis unditferentiated MPD, and hemorrhagic thrombocythemia. Semin Haematol 1975;12:409-32.

Leonard BJ, Israels MCG, Wilkinson JF. Alkaline phosphatase in the white cells in leukemia and leukemoid reactions. Lancet 1958;7:289-92.

Berlin NI. Diagnosis and classification of polycythemia. Semin Haematol 1975;12:339-51.

Ellis JT, Geller SA. The bone marrow in polycythemia vera. Semin Haematol 1975;12:433-44.

Gunz FW. In : Williums WJ, Beutler E, Erslev AJ, Rundles RW Essential thrombocythemia Hematology. 2nd ed. New York : McGraw-Hill, 19:806-9.

Silverstein MN. Primary or hemozhagic thrombocythemia. Arch Intern Med 1968;122:18-22.

Geller SA, Shapiro E. Acute leukemia as a natural sequel to primary thrombocythemia. Am J Clin Pathol 1982;77:3:353-6.

Koplow LS. Leukocyte alkaline phophatase cytochemistry : application and methods. Ann NY Acad Sci 1968;155:911.

Valentine NW, Beck WS. Phosphatase activity in health, leukocytosis and myelocytic leukemia. J lab Clin Med 195l;38:39-55.

Haznedar R, Yamac K. Gradual correction of leukocyte alkaline phosphatase in chronic myeloid leukemia after Interferon-a. Acta Haematol 1993;90:104-5.

Mitus XMJ, Mednicoff IB, Dameshek W. Leukocytic alkaline phosphatase in busulfan induced re.nissions of chronic granulocytic leukemia. Blood 1961;18:202-6.

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Published

2018-12-30

Issue

Vol. 9 No. 1: January-March 1999

Section

นิพนธ์ต้นฉบับ (Original article)

License

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