Autologous Peripheral Stem Cell Transplantation (Auto PSCT) in Non-Hodgkin's Lymphoma: Report of the First Successful Case of Department of Medicine, Phramongkutklao Hospital
Keywords:
Non-Hodgkin's lymphoma, Autologous peripheral stem cell transplantation, Stem cell mobilizationAbstract
Abstract: A 48-year-old Thai male was diagnosed NHI, large cell type, stage IV with mesenteric lymph nodes and bone marrow involvement. He was itially treated with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) for 6 cycles and was in complete remission (bone marrow had no lymphoma cell). He subsequently underwent autologous peripheral stem cell transplantation using high dose cyclophosphamide and granulocyte colony stimulating factor for stem cell mobilization. Then he received high-dose busulfan and cyclophosphamide and stem cell infusion. He had engraftment (absolute neutrophil count more than 500/jul. for 3 consecutive days) on day 9 but had complications of pseudomonas septicemia, shock and acute renal fallure required transfer to ICU. Affer hemodialysis his condition was improved and was able to discharge from ICU. This patient was the first successful case of Department of Medicine having an auto PSCT.
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