Pulmonary Hypertension in Hemophiliac HIV Positive Patient Receiving Long Term Prothrombin Complex Concentrate Therapy: Report of a Case and Review Literature
Keywords:
Hemophilia B, Thromboembolism, Prothrombin complex concentrationAbstract
Abstract: A case of 35-year-old Thai male patient having severe hemophilia B associated with HIV Infection was reported. The patient received prombin complex concentrate for the treatment of hemophilia. Two years following the treatment he developed compensated right heart failure. An acute severe pulmonary hypertension with intractable right heart failure developed following the use of large dose of prothrombin complex concentration within one week. His symptom was marked improved by low dose heparin therapy and fresh frozen plasma. There was no senous bleeding complication. Heparin low dose along with fresh frozen plasma given intervally seem to be helptul in the hemophillac patient who has severe pulmonary hypertension, right heart failure caused by pulmonary thromboembolism. The mechanism of thromboemboembolism due to HIV infection and prothrombin complex concentration was discussed. The literature regarding to the incidence, mechanism and guideline of treatment in this complication was reviewed.
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