Adverse Effects in Plateletpheresis Donors

Abstract

Abstract: In a retrospective study data from 4272 plateletpheresis male donors ages ranging from 17 to 58 vears at the Hemapheresis Unit, the Reference Laboratory, in WHO Co-Operative, the National Blood Centre. Thai Red Cross Society Hom January 2001 to December 2001 were analyzed. All donors took calcium gluconate (500 mg) orally before donation. Altogether, 4,251 donots completedthe plateletpheresis procedure. Eight hundred and sixty-nine donors had adverse effects (20.4%). Themost common adverse effect was paresthesias (98.73%). The most common area of paresthesias was penoral paresthesias followed by face. The association between adverse effect in plateletpheresis donors and age, weight, height, hematocrit, white blood cell count, platelet count, ACD used, blood volume process, numbers of cycle and diferent instruments were analyzed. It was found that there were significant trends in the relationship between adverse-event rate and weight, height, hematocrit, white blood cell count, platelet count and diferent instruments. Furthermore, the adverse-event rate of MCS2P instrument was lower than MCS3P and MCS Plus respectively. In conclusion, plateletoheresis donation is a safe undertaking, suitable for Thai voluntary blood donors, with a very low nisk of serious adverse effects. However, calcium replacement before donation and careful observation of donors is recommended.