Choriocarcinoma และ Klinefelter Syndrome

Authors

  • Rachata Lumkul Division of Hematology and Oncology, Department of Pediatrics, Phramongkutklao Hospital
  • Kwanjai Thanakitcharu Division of Endrocrinology, Department of Pediatrics, Phramongkutklao Hospital
  • Phaibul Punyarit Department of Pathology, Phramongkutklao College of Medicine
  • Kitti Torcharus Division of Hematology and Oncology, Department of Pediatrics, Phramongkutklao Hospital
  • Triroj Krutvecheo Division of Hematology and Oncology, Department of Pediatrics, Phramongkutklao Hospital
  • Thip Sriphaisal Division of Endrocrinology, Department of Pediatrics, Phramongkutklao Hospital

Keywords:

Klinefelter syndrome, Choriocarcinoma

Abstract

Abstract: A 13-year-old boy presented with diffuse metastatic pure choriocarcinoma at central nervous system, lung and skin nodules. No primary testicular tumor was found. The patient's bone marrow cell karyotype was 47,XXY which is consistent with Klinefelter syndrome. The patient was treated with combination chemotherapy and responded well. Pure choriocarcinoma, although rare as primary germ cell tumor, can be found about 15% of extragonadal germ cell tumor and 30% of germ cell tumors in Klinefelter syndrome (KS). The literature review confirms the association of germ cell tumors of nonseminomatous subtype and young median age group KS patient. The finding of extragonadal germ cell tumors in KS patient is also discussed.

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References

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Published

2020-12-30

Issue

Vol. 13 No. 1: January-March 2003

Section

รายงานผู้ป่วย (Case report)

License

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