การศึกษา Gene Frequencies ของ HLA-A และ -B Antigens ในอาสาสมัครบริจาคเซลล์ต้นกำเนิดเม็ดโลหิต
Keywords:
Human leukocyte antigen, Unrelated stem cell donorsAbstract
Abstract: In April 2002, the National Blood Centre, Thai Red Cross Society under control of the Medical Council Association established the Thai National Stem Cell Donor Registry Program, to facilitate the recruitment of unrelated stem cell donors into the donor's pool and search for a suitable donor for patients who lack the HLA identical sibling. From April 2002 to March 2003, 1,652 blood samples were collected from unrelated stem cell volunteer donors at the National Blood Centre, Thai Red Cross Society. HLA-A and -B antigens were typed by standard microlymphocytotoxicity test. This study found 26 HLA-A and 43 HLA-B antigens. HLA-A2 (27.57%), HLA-A11 (26.66%), HLA-A24 (17.37%), HLA-A33 (14.41%) and HLA-B46 (12.22%), HLA-B60 (10.74%), HLA-B13 (8.13%) were the most common. The less common gene frequencies were HLA-A23 (0.09%), HLA-A25 (0.03%), HLA-A80 (0.03%) and HLA-B45 (0.06%), HLA-B47 (0.06 %), HLA-B41 (0.03%) and HLA-B49 (0.03%). HLA-B42 and -B78 were not found. When comparing these frequencies with different Thai groups, HLA-A2, -A24, -A11, -A33 and -B46, -B60 and -B13 were found to be relatively common. Although there were some differences among HILA frequencies, this may be due to the fact that the family members of some subjects were included in this study, while the subjects in other ethnic group studies were random and unrelated, in addition to the different antisera used for testing and different population studies. Furthermore, the increase of stem cell volunteer donors provides a wide opportunity for stem cell transplantation for patients with rare HLA antigens.
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