Favism-induced severe hemolysis and methemoglobinemia in a patient with G6PD-deficiency: case report and literature review
Keywords:
Favism, Methemoglobinemia, G6PD deficiencyAbstract
Acquired methemoglobinemia in favism is uncommon. We report a 4.5-year-old Thai boy presenting pallor and cyanosis after fava bean ingestion. Oxygen saturation by pulse oximeter was 64% while arterial blood gas showed normal partial oxygen pressure, and methemoglobin level was 18.6%. Glucose-6-phosphate dehydrogenase (G6PD) deficient status was diagnosed by pathognomonic blood smear in an acute hemolytic settings despite negative G6PD fluorescent spot test. Blood transfusion was administered without providing methylene blue. G6PD Songklanagarind (196T>A) variant was later confirmed with moderately deficient G6PD enzymatic activity.
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