Ten-year retrospective review of clinical characteristics and treatment outcomes among Thai adult patients with Hodgkin lymphoma

Authors

  • Pisa Phiphitaporn Division of Hematology, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University
  • Nattiya Teawtrakul Division of Hematology, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University
  • Chinadol Wanitpongpun Division of Hematology, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University
  • Theerin Lanamtieng Division of Hematology, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University

Keywords:

Hodgkin lymphoma, clinical predictive factors, overall survival

Abstract

Introduction: Among Thai patients, clinical characteristics and treatment outcomes in Hodgkin lymphoma remain limited. This study aimed to evaluate the clinical manifestations and treatment outcomes of adult patients with Hodgkin lymphoma. Methods: A retrospective study was conducted on adult patients with Hodgkin lymphoma at Srinagarind Hospital. Clinical characteristics and potential clinical risk factors for Hodgkin lymphoma outcomes were collected. Clinical predictive factors and overall survival were demonstrated using Cox regression analysis and Kaplan-Meier curves. Results: In a total of 84 patients, the median aged was 46.2 years old. The most common subtype of classical Hodgkin lymphoma was nodular sclerosis (33, 39.2%) and mixed cellularity
(33, 39.2%). Most patients were stage II (31, 36.9%), and more than one half had constitutional symptoms (44, 52.4%). Complete remission was significantly associated with improved overall survival according to hazard ratio (HR) analysis (HR 0.4, p-value < 0.001). A significant association between poor overall survival and the existence of disease involvement in at least 3 sites was found (HR 1.8, p-value < 0.014). Those with early stage cancer had a greater overall survival rate than patients with advanced stage, according to Kaplan-Meier curves. Conclusion: In this study, mixed cellularity and nodular sclerosis were the two most common subtypes of Hodgkin lymphoma. The most common first line therapy was ABVD. Achieved complete remission was a protective factor associated with better survival. The presence of disease involvement in at least 3 sites was a substantial risk factor for poor outcomes.

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Published

2023-03-17

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นิพนธ์ต้นฉบับ (Original article)