Protein-losing enteropathy as a rare manifestation of neuroblastoma: a case report

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Natsaruth Songthawee
Pornpun Sripornsawan
Thirachit Chotsampancharoen


An 11-month-old girl presented with generalized edema, fever, and secretory diarrhea. Investigations revealed fat malabsorption and hypoalbuminemia; protein-losing enteropathy was confirmed with a Tc-99m albumin scan, and subsequent endoscopy with biopsy was done, which revealed intestinal lymphangiectasia without any evidence of malignancy. She was initially treated for primary intestinal lymphangiectasia with intravenous albumin and fat-free enteral feeding without improvement. After 2 months of hospitalization, a scalp nodule was noticed, and a biopsy result was consistent with neuroblastoma. Staging was completed, and it revealed that the primary tumor had originated from the left adrenal gland with multiple extensive local and distant metastases.


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