May-Hegglin Anomaly เลียนแบบ Immune Thrombocytopenia (ITP) ในผู้ใหญ่

Abstract

Abstract :

Five years ago, a 60-year-old female presented with severe thrombocytopenia on a check-up. She has never had bleeding symptoms. The patient was diagnosed as immune thrombocytopenia (ITP) after a bone marrow study. She has been treated with steroids and immunosuppressive agents for 4 years, but the platelet counts were still below 25 x109/L. Physical examination found no abnormality. However, blood and marrow smears showed giant platelets and basophilic inclusion bodies in granulocytes consistent with MYH9-related disorders. Therefore, all ITP treatment was discontinued. Recognition of these conditions is very important because these patients do not require therapy. Unnecessary treatments may put them at risk for serious side effects.