Ion Pair Complex for Drug Delivery System

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Sineerat Wantong
Pariyakorn Sublee
Sirilak Tepchan
Warisada Sila-On
Uracha Ruktanonchai
Wandee Rungseevijitprapa

Abstract

The purpose of this study was to develop a sustained drug delivery system based on a complex of drug and an agent of oppositely charges. In this study, cationic propranolol HCl was used to form complex with anionic sodium lauryl sulfate. Optimum ratio of propanolol and sodium lauryl sulfate that forms a water insoluble complex was investigated by turbidity and free propranolol HCl analysis. It was found that the ratio of propranolol HCl: sodium lauryl sulfate that gave the highest quantity of insoluble complex was 5.5:4.5 mmolar. Results from differential scanning calorimetry and x-ray diffraction analysis indicated the formation of a new substance. In vitro drug release in phosphate buffer pH 6.8 and 0.1 N HCl showed a slower dissolution rate of propranolol HCl-sodium lauryl sulfate complex microparticle than propranolol-sodium lauryl sulfate complex and propranolol HCl powder. Encapsulation of propranolol-sodium lauryl sulfate complex into microparticles gave 35.43±1.61% entrapment while entrapment of propranolol HCl to microparticle was only 2.26±0.19 %. In conclusion, the propranolol-sodium lauryl sulfate complex provides promising sustained drug delivery and was feasible to be encapsulated in microparticles for a more sustained drug release effect. However, a long term stability and bioavailability studies need to be further investigated.

Article Details

Section
Pharmacy

References

Adachi Y, Yoshida J, Kodera Y et al. 2006. Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes. Biochem and Biophys Res Commun 351: 165–170.

Aungst BJ, Hussain MA. 1992. Sustained popanolol delivery and increased oral bioavailability in dogs given popanolol laurate salt. Pharm Res 9: 1507-1508.

Choi SH, Park TG. 2000. Hydrophobic ion pair formation between leuprolide and sodium oleate for sustain release form biodegradable polymeric microspheres, Int J Pharm 203: 193-202.

Guerrero DQ, Allemann E, Fessi H, et al. 1997. Applications of the ion pair concept to hydrophillic substances with spacial emphasis on peptides. Pharm Res 14: 119-127.

Huang YB, Tsai YH, Yang WC, et al. 2004. Optimization of Sustained-Release Propranolol Dosage form Using Factorial Design and Response Surface Methodology. Biol Pharm Bull 27: 1626-1629.

Jeffrey DM, Mark CM, 1998. Hydrophobic Ion Pairing: Altering the Solubility Properties of Biomolecules. Pharm Res 15: 188-193.

Kositprapa U. 1996. Characterization and preparation of drug complexes and their delivery systems. The university of Texas. Austin Liu R. 2000. Water- insoluble Drug Formation. Interpharm Press. 214-217.

Nokhodchia A, Sania SN, Shadbada MR, et al. 2002. The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethyl- cellulose (HPMC) - Eudragit matrices. Eur J Pharm Biopharm 54: 349–356.

Norrman M, Hubalek F, Schluckebier G. 2007. Structural characterization of insulin NPH formulations. Eur J Pharm Sci 30: 414–423.

Sriwongjanya M, Bodmeier R, 1998. Effect of ion exchange resins on the drug release from matrix tablets, Eur J Pharm Biopharm 46: 321-327.

Takka S, Rajbhandari S, Sakr A. 2000. Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. Eur J Pharm Biopharm 52: 75-82.