Ion Pair Complex for Drug Delivery System
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Abstract
The purpose of this study was to develop a sustained drug delivery system based on a complex of drug and an agent of oppositely charges. In this study, cationic propranolol HCl was used to form complex with anionic sodium lauryl sulfate. Optimum ratio of propanolol and sodium lauryl sulfate that forms a water insoluble complex was investigated by turbidity and free propranolol HCl analysis. It was found that the ratio of propranolol HCl: sodium lauryl sulfate that gave the highest quantity of insoluble complex was 5.5:4.5 mmolar. Results from differential scanning calorimetry and x-ray diffraction analysis indicated the formation of a new substance. In vitro drug release in phosphate buffer pH 6.8 and 0.1 N HCl showed a slower dissolution rate of propranolol HCl-sodium lauryl sulfate complex microparticle than propranolol-sodium lauryl sulfate complex and propranolol HCl powder. Encapsulation of propranolol-sodium lauryl sulfate complex into microparticles gave 35.43±1.61% entrapment while entrapment of propranolol HCl to microparticle was only 2.26±0.19 %. In conclusion, the propranolol-sodium lauryl sulfate complex provides promising sustained drug delivery and was feasible to be encapsulated in microparticles for a more sustained drug release effect. However, a long term stability and bioavailability studies need to be further investigated.
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