Caffeine Topical Gel Formulation

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Thanaporn Amnualkit
Suthimaln Ingkatawornwong
Duangkhae Maneenuan
Kittichote Worachotekamjorn


Caffeine was used topically as one of many ingredients in various cosmetic preparations for reducing under-eye puffiness and dark circles. Gels containing 3% w/w caffeine as an active ingredient were prepared in this study. Suitable co-solvent systems and gel-forming concentrations were studied. Their effects on caffeine release from formulation were also studied. Suitable gel formulations consisted of carbopol Ultrez-21 as a gel-forming agent and propylene glycol (PG) as a co-solvent. The result showed that the increased concentration of Carbopol Ultrez-21, affected the formulation and thereby giving higher viscosity. However, all concentrations Carbopol Ultrez-21 studied (0.2%, 0.5%, 1%, 2% and 4%) did not affect caffeine release significantly. The percentage of PG in the formulation greatly affected caffeine release. Formulation containing 15% and 30% w/w PG gave release rate from Higuchi’s equation of 2.47 ± 0.26 mg/cm²/h½ and 2.37 ± 0.17 mg/cm²/h½, respectively which were lower when compared to release rate of 2.67 ± 0.07 mg/cm²/h½ from formulation containing 7.5% w/w PG. The best formulation of caffeine gel with good physical appearance and good release rate comprised of 3% caffeine, 0.5% carbopol Ultrez-21 and 7.5% PG.


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Amnuaikit c, Ikeuchi I, Ogawara K, et al. 2005. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. Inf J Pharm 289(2); 167-178.

Barry, BW. 1983. Dermatological formulations: percutaneous absorption, Marcel Dekker, New York.

Bonacucma, G, Cespi, M, Misici-Falzi, M, Palmieri, GF. 2006. Rheological, adhesive and release characterization of semisolid

Carbopol/tetraglycol systems. Int J Pharm 307(1): 129-140.

Chu, JS, Yu, DM, Amidon, GL, et al. 1992. Viscoelastic properties of polyacrylic acid gels in mixed solvents. Pharm Res 9: 1659-1663.

Collett, JH, Tobin, EA. 1979. Relationships between poloxamer structure and the solubilization of some para-substituted acetanilides. J Pharm Pharmacol 31: 174-177.

Dias, M, Farinha, A, Faustino, E, et al. 1999. Topical delivery of caffeine from some commercial formulations. Int J Pharm 182: 41-47.

Dreher, F, Fouchard, F, Patouillet, c, et al. 2002. Comparison of cutaneous bioavailability of cosmetic preparations containing caffeine or alpha-tocopherol applied on human skin models or human skin ex vivo at finite dose. Skin Pharmocol Physiol 15suppl. 1: 40-58.

Knight, D, Wilkinson, R, Hughes, B, et al. 2003. Caffeine Pharmacology, viewed, Accessed March 22, 2006.

Motoyoshi, K, Nozawa, S, Yoshimura, M, et al. 1984. The safety of propylene glycol and other humectants. Cosmet Toilet 99(10); 83-91.

Reynolds, JEF. 1993. Caffeine; Martindale The Extra Pharmacopoeia 30^ed. 1 The pharmaceutical press, London: pp.1315.

Schmolka, IR. 1967. Applications of pluronic polyols in the cosmetic industry. Am Perfum Cosmet 82(7): 25-30.

Secard, DL. 1962. Carbopol pharmaceuticals. Drug Cosmet Ind 90(1): 28-30, 113-116.