A Feasibility Study of Alcoholic-Alkaline Treated Glutinous Rice Starch for Film Coating

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Chiravut Pathumthanasup
Arom Tattawasart
Thaned Pongjanyakul
Padungkwan Chitropas

Abstract

The objectives of this research were to study the properties of alcoholic-alkaline treated glutinous rice
starch (AGS) and to investigate the properties of AGS free film and AGS coated tablets using propranolol
hydrochloride as a model drug. The film forming properties of AGS were compared with those of hydroxypropyl
methylcellulose E15LV (HPMC). The result showed that starch granule and gelatinization endotherm of AGS
was not appeared. This indicated that AGS was amorphous form, which was confirmed by powder XRD. The
swelling capacity and solubility of AGS in phosphate buffer pH 6.8 (PB 6.8) and 0.1 M HCl were higher than
those in distilled water (PW). The solubility of AGS film in PB 6.8 and 0.1 M HCl, was not different, but higher
than that using PW. The moisture adsorption and moisture permeability of AGS film were similar to HPMC film.
The moisture adsorption, disintegration time and T50% of the AGS coated tablets were similar to the HPMC
coated tablets. However, the AGS coated tablets showed rougher film surface than the HPMC coated tablets. It
can be concluded that AGS can be used as a film former and it displayed strong feasibility for film coating of
tablets.

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Section
Pharmaceutical Sciences

References

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