Development of Famotodine Floatinf Tablets
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Abstract
The purpose of this research was to develop famotidine floating tablet by study the influence of different
amount of hydroxypropyl methylcellulose 4000 (20 % and 30%), type of fillers (spray dried lactose
and microcrystalline cellulose PH102) and compression force (2000 pound and 4000 pound) on its release
rate and physical property. The floating tablets of famotidine were prepared by direct compression method.
The prepared tablets were evaluated for physical properties, floating properties (floating lag time, floating time and matrix integrity) and drug release properties. The results shows that tablet composition and mechanical strength have the greatest influence on the floating properties and drug release. Famotidine tablets contains 30% of HPMC 4000 was found to achieve optimum floating properties and the drug release from those tablets was sufficiently sustained (more than 8 hours). Increase in the compression force increased the floating lag time. It was found that using difference filler in this study showed the difference in the mechanism of drug release.
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References
Baumgartner S, Kristl J, Vrecer F, et al. Optimisation of floating matrix tablets and evaluation of theirgastric residence time. Int J Pharm 2000;195: 125 - 135.
Costa P, Lobo JMS. Modeling and comparison of dis-solution profiles, Review. Eur J Pharm Sci 2001; 13: 123 - 133.
Dave BS, Amin AF, Patal MM, et al. Gastroretentive drug delivery system of ranitidine hydrochlo-ride: formulation and In vitro evaluation. AAPS PharmSciTech 2004; 5(2) Article 34: 1- 6.
Gambhire MN, Ambade KW, Kurmi SD, et al. Development and In Vitro Evaluation of an Oral Floating Matrix Tablet Formulation of Diltiazem Hydrochloride. AAPS PharmSciTech 2007;8(3) : E1-E9.
Kulkarni A, Bhatia M. Development and evaluation of regioselective bilayer floating tablets of atenolol and lovastatin for biphasic release profile. IJPR2009; 8(1): 15 - 25.
Jaimini M, Rana AC, Tanwar YS. Formulation and evaluation of famotidine floating tablets. Curr Drug Deliv 2007; 4: 51 - 55.
Martinez IJ, Barreda TQ, Robles LV. Sustained delivery of captopril from floating matrix tablets. Int J Pharm 2008; 362: 37 - 43.
Merchant HA, Shoaib HM, Tazeen J, et al. Once daily tablet formulation and In vitro release evaluation of cefpodoxine using hydroxypropyl methylcellulose: A technical note. AAPS PharmSciTech 2006; 7(3) Article 78:E1 - E6.
Nur AO, Zhang JS. Captopril floating and/or bioadhesive tablets: design and release kinetics. Drug Dev Ind Pharm 2000; 26:965 - 969.
Pare A, Yadav SK, Patil UK. Formulation and evaluation of effervescent floating tablet of amlodipine besylate. Research J Pharm And Tech 2008; 1(4): Oct. - Dec. 526 - 530.
Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev2001; 139 - 157.
Singh BN, Kim KH. Floating drug delivery systems :an approach to oral controlled drug delivery via gastric retention. J Controlled Release2000; 63: 235 - 259.
Tadros MI. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: Development, optimization and in vitro-in vivo evaluation in healthy human volunteers. Eur JPharm Biopharm 2010;74: 332 - 339.